Aryne 1,2,3-Trifunctionalization with Aryl Allyl Sulfoxides
Aryne 1,2,3-Trifunctionalization with Aryl Allyl Sulfoxides
复制标题
用芳基烯丙基亚砜进行芳基 1,2,3-三官能化
DOI：
10.1021/jacs.6b06981
复制
发表时间：
2016-08-31
影响因子：
15
通讯作者：
Li, Yang
中科院分区：
文献类型：
--
作者：
Li, Yuanyuan;Qiu, Dachuan;Li, Yang
用芳基烯丙基亚砜进行芳炔1，2，3-三取代反应，其特征是在苯环的邻位引入C-S，C-O和C-C键。反应条件温和，底物范围广。初步的机理研究表明芳炔与S=O键的级联式[2 + 2]反应、烯丙基S -> O迁移和Claisen重排。
An aryne 1,2,3-trisubstitution with aryl allyl sulfoxides is accomplished, featuring, an incorporation of C-S, C-O, and C-C bonds on the Consecutive positions of a benzene ring. The reaction condition is mild with broad substrate scope. Preliminary mechanistic study suggests a cascade formal [2 + 2] reaction of aryne with S=O bond, an allyl S -> O migration, and a Claisen rearrangement.