Nestin and small heat shock protein expression on reactive astrocytes and endothelial cells in cerebral abscess
Nestin and small heat shock protein expression on reactive astrocytes and endothelial cells in cerebral abscess
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DOI：
10.1016/s0168-0102(02)00126-8
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发表时间：
2002-10-01
影响因子：
2.9
通讯作者：
Kim, TS
中科院分区：
文献类型：
--
作者：
Ha, Y;Choi, JU;Kim, TS
脑脓肿导致广泛的包膜形成，是限制微生物传播的重要屏障。反应性星形胶质细胞和内皮细胞与纤维细胞一起是脓肿包膜的主要细胞成分。导致这些细胞迁移和增殖的分子机制仍然是推测的。中间丝(IF)、巢蛋白和小分子热休克蛋白(SHSP)是发育调节蛋白。在这项研究中，我们发现Nestin不仅在反应性星形胶质细胞中重新诱导表达，而且在囊膜胶质细胞区域的内皮细胞中也重新诱导表达。表达巢蛋白的星形胶质细胞和内皮细胞也表达sHSPs，如热休克蛋白27(HSP27)和α-结晶蛋白。这些结果表明，致病微生物诱导的炎症应激导致胚胎细胞骨架蛋白转化为巢蛋白，反应性星形胶质细胞和血管内皮细胞中sHSPs表达增加。(C)2002年爱尔兰爱思唯尔科学有限公司和日本神经科学学会。版权所有。
Cerebral abscess results in an extensive capsular formation, which is an important limiting barrier for the spread of microorganism. Reactive astrocytes and endothelial cells are major cellular components of the abscess capsule together with fibrocytes. Molecular pathogenesis that results in the migration and proliferation of these cells remain speculative. Intermediate filament (IF) nestin and small heat shock proteins (sHSP) are developmentally regulated protein. In this study, we found that nestin expression is re-induced in not only reactive astrocytes, but also in endothelial cells in the gliotic area of the capsule. These nestin expressing astrocytes and endothelial cells also expressed sHSPs, such as heat shock protein 27 (HSP27) and alphaB-crystalline. These results indicated that embryonic reversions of cytoskeletal proteins to nestin and the increased expression of sHSPs in in reactive astrocytes and endothelial cells are caused by pathogenic microorganism induced inflammatory stress. (C) 2002 Elsevier Science Ireland Ltd. and the Japan Neuroscience Society. All rights reserved.