No-go dominant brain activity in human inferior prefrontal cortex revealed by functional magnetic resonance imaging
No-go dominant brain activity in human inferior prefrontal cortex revealed by functional magnetic resonance imaging
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DOI：
10.1046/j.1460-9568.1998.00167.x
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发表时间：
1998-03-01
影响因子：
3.4
通讯作者：
Miyashita, Y
中科院分区：
文献类型：
--
作者：
Konishi, S;Nakajima, K;Miyashita, Y
我们研究了前额叶皮层的反应抑制功能与去/不去任务使用功能性磁共振成像在五个人类受试者。去/不去任务包括去和不去试验随机给出大致相同的概率。在进行试验中，呈现一个绿色方块，受试者必须通过使用他们的右手或左手拇指迅速按下按钮来做出反应，但在不进行试验中，呈现一个红色方块，受试者被指示不要做出反应。当前额叶皮层中的大脑活动在不去尝试中占主导地位时，这种不去主导的大脑活动将反映抑制内在反应倾向的神经过程。我们使用了一种新的图像数据分析策略，通过这种策略，可以分别分析去或不去试验中的瞬时脑活动，并寻找在不去试验中的脑活动占主导地位的前额叶区域。我们发现，在受试者中，右额下沟后部的不去优势病灶是可重复的。无论使用右手还是左手，这都是正确的。这些结果表明，在前额叶皮层的这一区域是相关的神经机制的反应抑制功能。
We investigated the response inhibition function of the prefrontal cortex associated with the go/no-go task using functional magnetic resonance imaging in five human subjects. The go/no-go task consisted of go and no-go trials given randomly with roughly equal probability. In go trials a green square was presented and the subjects had to respond by promptly pushing a button using their right or left thumbs, but in no-go trials a red square was presented and subjects were instructed not to respond. When brain activity in no-go trials is dominant over that in go trials in areas in the prefrontal cortex, this no-go dominant brain activity would reflect the neural processes for inhibiting inherent response tendency. We used a new strategy of image data analysis by which transient brain activity in go or no-go trials can be analysed separately, and looked for the prefrontal areas in which the brain activity in no-go trials is dominant over that in go trials. We found the no-go dominant foci in the posterior part of the right inferior frontal sulcus reproducibly among the subjects. This was true whether the right or left hand was used. These results suggest that this region in the prefrontal cortex is related to the neural mechanisms underlying the response inhibition function.