Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor α knockout mice
Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor α knockout mice
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DOI：
10.1016/s0304-3940(01)02083-3
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发表时间：
2001-08-31
影响因子：
2.5
通讯作者：
Foster, TC
中科院分区：
文献类型：
--
作者：
Fugger, HN;Kumar, A;Foster, TC
在应用17β -雌二醇（E - 2）后，大鼠海马脑片的基础突触传递迅速增强。在当前研究中，我们检测了经典的基因组受体——雌激素受体α（ERα）在介导E - 2对突触传递的影响中所起的作用。E - 2（100 pM）可增强性腺切除的雄性和雌性雌激素受体α基因敲除（ERα KO）小鼠及其野生型（WT）同窝小鼠海马脑片的细胞外突触反应。未观察到性别差异，然而，在野生型小鼠中，场电位的增强更为显著。雌激素受体拮抗剂并不能阻断ERα KO小鼠中E - 2介导的突触反应增强。结果表明，E - 2对突触传递的快速作用不是由ERα介导的，然而，ERα似乎可调节对突触传递的非基因组影响。（C）2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
Hippocampal slices from rats exhibit a rapid increase in basal synaptic transmission following 17 beta -estradiol (E-2) application. In the current study we examined the role of the classic genomic receptor, estrogen receptor alpha (ER alpha), in mediating E-2 effects on synaptic transmission. E-2 (100 pM) increased the extracellular synaptic response in hippocampal slices from gonadectomized male and female mice lacking a functional ER alpha knockout (ER alpha KO) and wild-type (WT) littermates. No sexually dimorphic differences were observed, however, the increase in the field potential was more pronounced in WT mice. ER antagonists did not block E-2 mediated growth of the synaptic response in ERaKO mice. The results suggest that the rapid effect of E-2 on synaptic transmission is not mediated by ER alpha, however, ER alpha appears to modulate non-genomic influences on synaptic transmission. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.