Phase-to-rate transformations encode touch in cortical neurons of a scanning sensorimotor system
Phase-to-rate transformations encode touch in cortical neurons of a scanning sensorimotor system
复制标题
DOI：
10.1038/nn.2283
复制
发表时间：
2009-04-01
影响因子：
25
通讯作者：
Kleinfeld, David
中科院分区：
文献类型：
--
作者：
Curtis, John C.;Kleinfeld, David
感官知觉涉及编码外部刺激和管理改变感觉场的身体位置变化的影响的双重挑战。为了研究用于整合由外部刺激和运动活动引起的感觉信号的机制，我们记录了训练大鼠有节奏地扫描触须以寻找目标的过程。我们发现了一个选定的人口在初级躯体感觉皮层的神经元，是短暂的兴奋的汇合触摸由一个单一的触须和触须运动的搅拌周期的阶段;不同的单位有不同的首选阶段。这种条件响应使得啮齿动物能够估计坐标系中的对象位置，该坐标系被归一化为电机输出的轨迹，如由搅拌周期中的相位所定义的，而不是鼻毛相对于面部的角度。基础计算与抑制性分流的门控一致。
Sensory perception involves the dual challenge of encoding external stimuli and managing the influence of changes in body position that alter the sensory field. To examine mechanisms used to integrate sensory signals elicited by both external stimuli and motor activity, we recorded from rats trained to rhythmically sweep their vibrissa in search of a target. We found a select population of neurons in primary somatosensory cortex that are transiently excited by the confluence of touch by a single vibrissa and the phase of vibrissa motion in the whisk cycle; different units have different preferred phases. This conditional response enables the rodent to estimate object position in a coordinate frame that is normalized to the trajectory of the motor output, as defined by phase in the whisk cycle, rather than angle of the vibrissa relative to the face. The underlying computation is consistent with gating by an inhibitory shunt.