Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan
Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan
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DOI：
10.1007/s00330-019-06542-9
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发表时间：
2020-04-01
影响因子：
5.9
通讯作者：
Oei, Edwin H. G.
中科院分区：
文献类型：
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作者：
Eijgenraam, Susanne M.;Chaudhari, Akshay S.;Oei, Edwin H. G.
目的 使用放射学膝关节 OA 作为参考标准，评估 5 分钟定量双回波稳态 (qDESS) 序列在临床 OA 人群中同步 T-2 测量软骨和半月板以及结构性膝骨关节炎 (OA) 评估的辨别力。方法 纳入 53 名受试者，根据放射学和临床膝关节 OA 分为三组：20 名受试者无 OA（Kellgren-Lawrence 分级 (KLG) 0），18 名受试者患有轻度 OA (KLG2)，15 名受试者患有中度 OA (KLG3)。所有患者均接受 5 分钟 qDESS 扫描。我们测量了四个软骨和四个半月板感兴趣区域 (ROI) 的 T-2 弛豫时间，并使用带有多平面重新格式化的 qDESS 通过 MRI 骨关节炎膝关节评分 (MOAKS) 进行结构性 OA 评估。使用方差分析计算 T-2 值和 MOAKS 的组间差异。通过序数变量的相关分析来评估参考标准（即放射学膝关节 OA）与 T-2 和 MOAKS 的相关性。结果 在软骨中，无、轻度和中度 OA 的平均 T-2 值分别为 36.1 +/- SD 4.3、40.6 +/- 5.9 和 47.1 +/- 4.3 ms（p < 0.001）。在半月板中，无、轻度和中度 OA 的平均 T-2 值分别为 15 +/- 3.6、17.5 +/- 3.8 和 20.6 +/- 4.7 毫秒 (p < 0.001)。在所有 ROI 中，射线照相 OA 和 T-2 之间以及射线照相 OA 和 MOAKS 之间均存在统计学显着相关性 (p < 0.05)。结论 使用单次 5 分钟 qDESS 扫描对软骨和半月板进行定量 T-2 和结构评估，可以区分不同级别的放射学 OA，证明 qDESS 作为 OA 成像有效工具的潜力。
Objectives To assess the discriminative power of a 5-min quantitative double-echo steady-state (qDESS) sequence for simultaneous T-2 measurements of cartilage and meniscus, and structural knee osteoarthritis (OA) assessment, in a clinical OA population, using radiographic knee OA as reference standard. Methods Fifty-three subjects were included and divided over three groups based on radiographic and clinical knee OA: 20 subjects with no OA (Kellgren-Lawrence grade (KLG) 0), 18 with mild OA (KLG2), and 15 with moderate OA (KLG3). All patients underwent a 5-min qDESS scan. We measured T-2 relaxation times in four cartilage and four meniscus regions of interest (ROIs) and performed structural OA evaluation with the MRI Osteoarthritis Knee Score (MOAKS) using qDESS with multiplanar reformatting. Between-group differences in T-2 values and MOAKS were calculated using ANOVA. Correlations of the reference standard (i.e., radiographic knee OA) with T-2 and MOAKS were assessed with correlation analyses for ordinal variables. Results In cartilage, mean T-2 values were 36.1 +/- SD 4.3, 40.6 +/- 5.9, and 47.1 +/- 4.3 ms for no, mild, and moderate OA, respectively (p < 0.001). In menisci, mean T-2 values were 15 +/- 3.6, 17.5 +/- 3.8, and 20.6 +/- 4.7 ms for no, mild, and moderate OA, respectively (p < 0.001). Statistically significant correlations were found between radiographic OA and T-2 and between radiographic OA and MOAKS in all ROIs (p < 0.05). Conclusion Quantitative T-2 and structural assessment of cartilage and meniscus, using a single 5-min qDESS scan, can distinguish between different grades of radiographic OA, demonstrating the potential of qDESS as an efficient tool for OA imaging.