Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system?
Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system?
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DOI：
10.1042/bst0320640
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发表时间：
2004-08-01
影响因子：
3.9
通讯作者：
Cheetham, ME
中科院分区：
文献类型：
--
作者：
Chapple, JP;van der Spuy, J;Cheetham, ME
热休克蛋白70的伴侣机器通过共伴侣芯片与泛素-蛋白酶体系统功能相连。在这篇文章中，我们讨论了神经元DNAJ蛋白HSJ1a和HSJ1b可能代表细胞蛋白质折叠和降解机制之间的进一步联系的证据。我们已经证明HSJ1蛋白包含假定的泛素相互作用基序，并可以调节视紫红质的细胞处理，视紫红质是一种蛋白质，当它错误折叠时，它会被蛋白酶体降解。
The heat-shock protein 70 chaperone machine is functionally connected to the ubiquitin-proteasome system by the co-chaperone CHIP. In this article, we discuss evidence that the neuronal Dnaj proteins HSJ1a and HSJ1b may represent a further link between the cellular protein folding and degradation machineries. We have demonstrated that HSJ1 proteins contain putative ubiquitin interaction motifs and can modulate the cellular processing of rhodopsin, a protein that is targeted for degradation by the proteasome when it is misfolded.