Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals.
Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals.
复制标题
屈大麻酚对吗啡诱导的动物多巴胺相关行为效应的影响。
作者：
Mori T;Shibasaki M;Abe M;Udagawa Y;Suzuki T.
本研究检查了屈大麻酚（一种美国FDA批准的合成大麻素受体激动剂）对吗啡（一种原型μ阿片受体激动剂）诱导的动物多巴胺相关行为的影响。屈大麻酚抑制吗啡在大鼠中的奖赏效应和在雪貂中的催吐效应。此外，屈大麻酚显著减弱了吗啡诱导的中脑背核多巴胺释放增加，这表明屈大麻酚对吗啡诱导行为的抑制作用至少部分是通过调节多巴胺能系统介导的。由于大麻素受体激动剂已被证明可增强吗啡的抗伤害作用，因此使用屈大麻酚作为佐剂可用于预防μ阿片受体激动剂用于控制疼痛时的不良反应。Synapse 66：931-937，2012.© 2012 Wiley Periodicals，Inc.
The present study examined the effects of dronabinol, a United States FDA‐approved synthetic cannabinoid receptor agonist, on morphine (a prototypic μ‐opioid receptor agonist)‐induced dopamine‐related behaviors in animals. Dronabinol suppressed the rewarding effects of morphine in rats and its emetic effects in ferrets. Furthermore, the morphine‐induced increase in dopamine release from the nucleus accumbens was significantly attenuated by dronabinol, which indicated that the suppressive effects of dronabinol on morphine‐induced behaviors are at least in part mediated by regulation of the dopaminergic system. Since cannabinoid receptor agonists have been shown to enhance the antinociceptive effects of morphine, the use of dronabinol as an adjuvant could be useful for preventing the adverse effects of μ‐opioid receptor agonists when used to control pain. Synapse 66:931–937, 2012. © 2012 Wiley Periodicals, Inc.