Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene.
Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene.
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猿肉瘤病毒 onc 基因的人类同源物 (c-sis) 的染色体定位。
DOI：
10.1126/science.6291150
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Croce,CM
中科院分区：
文献类型：
--
作者：
Dalla-Favera,R;Gallo,RC;Giallongo,A;Croce,CM
22号染色体的非随机染色体重排已在不同的人类恶性肿瘤中发现。作为c-sis探针与来自小鼠-人类体细胞杂种的DNA的Southern印迹杂交的结果，猿肉瘤病毒的转化基因的人类同源物（c-sis）被分配到染色体22。还分析了胸苷激酶缺陷小鼠细胞和携带22号染色体q11-qter区域易位至17号染色体的人成纤维细胞之间的杂交。这些研究表明，人c-sis基因位于22 q11>qter区域。
Nonrandom chromosome rearrangements of chromosome 22 have been identified in different human malignancies. As a result of Southern blot hybridization of a c-sisprobe to DNA's from mouse-human somatic cell hybrids, the human homolog (c-sis) of the transforming gene of simian sarcoma virus was assigned to chromosome 22. Hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the region q11-qter of chromosome 22 to chromosome 17 were also analyzed. These studies demonstrate that the human c-sisgene is on region 22q11>qter.