Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia.
Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia.
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DOI：
10.1038/srep42480
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发表时间：
2017-02-16
影响因子：
4.6
通讯作者：
Azuma N
中科院分区：
文献类型：
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作者：
Katagiri S;Nishina S;Yokoi T;Mikami M;Nakayama Y;Tanaka M;Azuma N
我们研究了视神经发育不全（ONH）患者的视网膜结构和功能。分析了18例ONH患者的29只眼和21例对照患者的21只眼。进行了光谱域光学相干断层扫描（SD-OCT）、全视野视网膜电图（FF-ERG）和局灶性黄斑ERG（FM-ERG）检查。黄斑区的SD-OCT分析显示，在鼻侧和颞侧，神经节细胞复合体（GCC）明显变薄（P < 0.05），但从内核层（INL）到视网膜色素上皮（RPE）的厚度仅在鼻侧变薄（P < 0.05）。视乳头周围区的SD-OCT分析显示，从INL到RPE，视网膜神经纤维层明显变薄（P < 0.05）。水平SD-OCT图像显示可变的中心凹异常。FF-ERG分析显示明视觉负反应的振幅显著降低（P < 0.05），隐反应时间保持不变。其他FF-ERG成分的振幅和隐时无显著差异。FM-ERG分析显示，各成分的振幅均显著降低（P < 0.05），但隐式时间均保持不变。目前的研究显示，与对照组相比，ONH眼的视网膜结构和功能发生了变化，表现为视网膜神经节细胞（RGCs）及其轴突减少，中心凹异常，除RGCs及其轴突外，周边视网膜保留。
We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were performed. SD-OCT analysis of the macular region showed significant ganglion cells complex (GCC) thinning nasally and temporally (P < 0.05), but the thickness from the inner nuclear layer (INL) to the retinal pigment epithelium (RPE) became thinner only nasally (P < 0.05). SD-OCT analysis of the circumpapillary region showed significant thinning in the retinal nerve fiber layer and from the INL to the RPE (P < 0.05). The horizontal SD-OCT images showed variable foveal abnormalities. FF-ERG analysis showed significantly reduced amplitudes (P < 0.05) and preserved implicit time in the photopic negative response. The amplitudes and implicit times of the other FF-ERG components did not differ significantly. FM-ERG analysis showed significantly reduced amplitudes (P < 0.05) but preserved implicit times in all components. The current study showed the change of retinal structure and function in eyes with ONH compared with those with control, representing by decreased retinal ganglion cells (RGCs) and their axons, foveal abnormalities, and preserved peripheral retina except for the RGCs and their axons.