Water ingestion increases sympathetic vasoconstrictor discharge in normal human subjects
Water ingestion increases sympathetic vasoconstrictor discharge in normal human subjects
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DOI：
10.1042/cs20000177
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发表时间：
2001-03-01
期刊：
影响因子：
6
通讯作者：
Mary, DASG
中科院分区：
文献类型：
--
作者：
Scott, EM;Greenwood, JP;Mary, DASG
在自主神经功能衰竭患者和老年人中观察到对饮水的显著加压反应，这归因于交感血管收缩剂激活，尽管在交感神经机制完整的健康受试者中没有这种加压反应。我们研究了正常人饮水是否影响外周交感神经放电及其对血管阻力的影响。在9名正常人受试者中，我们研究了水摄入对腓神经肌肉交感神经活动的影响，作为多单位爆发（肌肉交感神经活动; MSNA）和具有血管收缩功能的单单位冲动（s-MSNA），并对小腿血管阻力影响120 min。在每个受试者中，饮水引起s-MSNA和MSNA增加，并在摄入后30 min达到峰值;分别增加（平均值+/-S.E.M.）从42+/-4至58+/-5脉冲/100次搏动（P < 0.01）和从36+/-4至51+/-5脉冲/100次搏动（P < 0.001）。小牛血管阻力和血浆去甲肾上腺素水平相应增加。所有这些数据之间存在显著相关性。总之，MSNA的测量提供了直接证据，即正常人受试者饮水增加交感神经交通，导致外周血管收缩。这种交感神经激活并不伴随着动脉血压的显著变化。
A marked presser response to water drinking has been observed in patients with autonomic failure and in the elderly, and has been attributed to sympathetic vasoconstrictor activation, despite the absence of such a presser response in healthy subjects with intact sympathetic mechanisms. We investigated whether water drinking in normal subjects affected peripheral sympathetic neural discharge and its effect on vascular resistance. In nine normal human subjects, we examined the effect of water ingestion on muscle sympathetic neural activity from the peroneal nerve, as multi-unit bursts (muscle sympathetic nerve activity; MSNA) and as single-unit impulses (s-MSNA) with vasoconstrictor function, and on calf vascular resistance for 120 min. In each subject, water ingestion caused increases in s-MSNA and MSNA which peaked at 30 min after ingestion; they increased respectively (mean+/-S.E.M.) from 42+/-4 to 58+/-5 impulses/100 beats (P < 0.01) and from 36+/-4 to 51+/-5 bursts/100 beats (P < 0.001). There were corresponding increases in calf vascular resistance and in plasma noradrenaline levels. A significant correlation occurred between all of these data. In conclusion, measurement of MSNA has provided direct evidence that water drinking in normal human subjects increases sympathetic nerve traffic, leading to peripheral vasoconstriction. This sympathetic activation was not accompanied by significant changes in arterial blood pressure.