Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses.
Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses.
复制标题
DOI：
10.3109/17435390.2011.647929
复制
发表时间：
2013-03
期刊：
影响因子：
5
通讯作者：
Rojanasakul Y
中科院分区：
文献类型：
--
作者：
Azad N;Iyer AK;Wang L;Liu Y;Lu Y;Rojanasakul Y
单壁碳纳米管（SWCNTs）是一种纤维状纳米颗粒，广泛用于包括药物输送在内的各种应用。SWCNTs目前因其可能的细胞毒性而受到特别关注。最近的报告表明，接触纳米颗粒会导致肺纤维化。我们报道swcnts介导的纤维生成和血管生成调节因子的相互作用导致血管生成增加，这是一个新的发现，进一步了解swcnts诱导的细胞毒性。SWCNTs通过活性氧调控的p38丝裂原活化蛋白激酶（MAPK）磷酸化诱导纤维形成。SWCNTs激活p38 MAPK可诱导转化生长因子(TGF)-β1和血管内皮生长因子（VEGF）的表达。TGF-β1和VEGF均显著促进SWCNTs的纤维增殖和胶原诱导作用。有趣的是，TGF-β1与VEGF之间存在正反馈回路。纤维生成介质和血管生成介质的相互作用导致SWCNTs对血管生成的反应增加。总的来说，这项研究揭示了swcnts诱导的纤维生成和血管生成的关键信号分子。
Single-walled carbon nanotubes (SWCNTs) are fibrous nanoparticles that are being used widely for various applications including drug delivery. SWCNTs are currently under special attention for possible cytotoxicity. Recent reports suggest that exposure to nanoparticles leads to pulmonary fibrosis. We report that SWCNT-mediated interplay of fibrogenic and angiogenic regulators leads to increased angiogenesis, which is a novel finding that furthers the understanding of SWCNT-induced cytotoxicity. SWCNTs induce fibrogenesis through reactive oxygen species-regulated phosphorylation of p38 mitogen-activated protein kinase (MAPK). Activation of p38 MAPK by SWCNTs led to the induction of transforming growth factor (TGF)-β1 as well as vascular endothelial growth factor (VEGF). Both TGF-β1 and VEGF contributed significantly to the fibroproliferative and collagen-inducing effects of SWCNTs. Interestingly, a positive feedback loop was observed between TGF-β1 and VEGF. This interplay of fibrogenic and angiogenic mediators led to increased angiogenesis in response to SWCNTs. Overall this study reveals key signalling molecules involved in SWCNT-induced fibrogenesis and angiogenesis.
登录
查看更多内容
影响因子：
56.9
作者：
HAN, J;LEE, JD;ULEVITCH, RJ
通讯作者：
ULEVITCH, RJ
影响因子：
11.4
作者：
Beyaert, R;Cuenda, A;Fiers, W
通讯作者：
Fiers, W
影响因子：
10
作者：
Khalil, N;Parekh, TV;Gold, LI
通讯作者：
Gold, LI
影响因子：
5.6
作者：
Huh, Jeong-Eun;Nam, Dong-Woo;Lee, Jae-Dong
通讯作者：
Lee, Jae-Dong
DOI：
10.1084/jem.20061273
发表时间：
2007-05-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kang HR;Lee CG;Homer RJ;Elias JA
通讯作者：
Elias JA