Clinical Application of Asparaginase Activity Levels Following Treatment With Pegaspargase
Clinical Application of Asparaginase Activity Levels Following Treatment With Pegaspargase
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DOI：
10.1002/pbc.25299
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发表时间：
2015-06-01
影响因子：
3.2
通讯作者：
Hunger, Stephen P.
中科院分区：
文献类型：
--
作者：
Bleyer, Archie;Asselin, Barbara L.;Hunger, Stephen P.
天冬酰胺酶是一种用于治疗急性淋巴细胞白血病和相关形式的非霍奇金淋巴瘤的酶，它消耗天冬酰胺，导致淋巴母细胞死亡。与大多数化疗药物不同，天冬酰胺酶是一种外源蛋白，可导致临床过敏和/或沉默超敏反应，并产生中和天冬酰胺酶的中和抗体。在北美，天冬酰胺酶活性水平现在可以通过市售的检测方法获得，用于治疗药物监测和潜在过敏反应的研究。在此，我们提供了在用培门冬酶处理后临床应用该测定以评价疑似超敏反应和/或沉默失活的建议和相应算法。儿科血液癌症2015;62：1102-1105。(c)2014 Wiley Periodicals，Inc.
Asparaginase, an enzyme used to treat acute lymphoblastic leukemia and related forms of nonHodgkin lymphoma, depletes asparagine, which leads to lymphoblast cell death. Unlike most chemotherapeutic agents, asparaginase is a foreign protein that can result in clinical allergy and/or silent hypersensitivity with production of neutralizing antibodies that inactivate asparaginase. In North America, asparaginase activity levels can now be obtained via a commercially available assay, for therapeutic drug monitoring and investigation of potential allergic reactions. Herein, we provide recommendations and a corresponding algorithm for the clinical application of this assay after treatment with pegaspargase to evaluate suspected hypersensitivity reactions and/or silent inactivation. Pediatr Blood Cancer 2015;62:1102-1105. (c) 2014 Wiley Periodicals, Inc.