Whole milk consumption is associated with lower risk of coronary artery calcification progression: evidences from the Multi-Ethnic Study of Atherosclerosis
Whole milk consumption is associated with lower risk of coronary artery calcification progression: evidences from the Multi-Ethnic Study of Atherosclerosis
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饮用全脂牛奶与降低冠状动脉钙化进展风险相关：来自动脉粥样硬化多种族研究的证据
DOI：
10.1007/s00394-020-02301-5
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发表时间：
2020-06-24
影响因子：
5
通讯作者：
Huang, Hui
中科院分区：
文献类型：
--
作者：
Ghosh, Sounak;He, Wanbing;Huang, Hui
目的冠状动脉钙化(CAC)进展是心血管疾病(CVD)发病率和死亡率的重要预测指标。然而，全脂牛奶和CAC进展之间的联系仍不清楚。最近的研究强调了全脂牛奶中的短链脂肪酸(SCFA)对心血管疾病的有益作用。在这项研究中，我们试图研究全脂牛奶摄入量与CAC进展的关系，以及SCFA在其中的潜在作用。方法我们分析了来自动脉粥样硬化多种族研究(MESA)的5273名参与者的基于人群的队列，他们在基线时完成了一份饮食调查问卷。在基线和随后的后续检查中，通过多探测器计算机断层扫描(MDCT)和Agatston评分测量CAC。CAC进展被定义为在基线检查后的随访中CAC得分增加。结果饮用全脂牛奶的受试者较从不或很少饮用全脂牛奶的受试者表现出更低的CAC和CAC进展(分别为P<；0.001和P=0.010)。此外，多变量Logistic回归分析显示，摄入全脂牛奶与较低的CAC进展独立相关(OR 0.765；95%CI 0.600-0.977；P=0.032)，尤其是在男性、年龄较大的参与者中
Purpose Coronary artery calcification (CAC) progression is a strong predictor of cardiovascular disease (CVD) morbidity and mortality. However, the association between whole milk and CAC progression remains unknown. Recent studies highlighted beneficial effects of short chain fatty acids (SCFA) from whole milk on CVD. In this study, we attempted to investigate the relationship between whole milk consumption and CAC progression, and the potential effect of SCFA in it. Methods We analyzed a population-based cohort with 5273 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who completed a dietary questionnaire at baseline. CAC was measured at baseline and subsequent follow-up examinations by multi-detector computed tomography (MDCT) scans with Agatston scores. CAC progression was defined as increased CAC scores in the follow-up from the baseline exam. Results Participants consuming whole milk exhibited lower baseline CAC and CAC progression than those who never/rarely consumed whole milk (P < 0.001 andP = 0.010, respectively). Moreover, multivariable logistic regression analysis demonstrated that whole milk intake was independently associated with lower CAC progression (OR 0.765; 95% CI 0.600-0.977;P = 0.032), especially in males, participants with age