Olfactory Coding with Patterns of Response Latencies
Olfactory Coding with Patterns of Response Latencies
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DOI：
10.1016/j.neuron.2010.08.005
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发表时间：
2010-09-09
期刊：
影响因子：
16.2
通讯作者：
Schild, Detlev
中科院分区：
文献类型：
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作者：
Junek, Stephan;Kludt, Eugen;Schild, Detlev
脊椎动物嗅球中的僧帽/簇状（M/T）细胞的时空模式对气味的编码一直存在争议。受行为研究的时间限制，我们研究了气味诱发的第一峰潜伏期中包含的信息。使用同时记录的几十个M/T细胞的高时间分辨率和定量集成相关技术，我们表明，延迟模式，特别是延迟等级模式，是高度气味特异性和可重复性。他们可靠地预测气味的身份以及气味浓度在一个单一的试验基础上，并在短时间内，事实上，更可靠的模式比发射率。此外，我们表明，潜伏期排名表现出更好的再现性在M/T细胞的水平比嗅觉受体神经元。我们的研究结果表明，M/T细胞的潜伏模式包含了高级大脑中心识别气味及其浓度所需的所有信息。
The encoding of odors by spatiotemporal patterns of mitral/tufted (M/T) cells in the vertebrate olfactory bulb has been discussed controversially. Motivated by temporal constraints from behavioral studies, we investigated the information contained in odor-evoked first-spike latencies. Using simultaneous recordings of dozens of M/T cells with a high temporal resolution and quantitative ensemble correlation techniques, we show that latency patterns, and in particular latency rank patterns, are highly odor specific and reproducible. They reliably predict the odor identity as well as the odor concentration on a single-trial basis and on short timescales in fact, more reliably than patterns of firing rates. Furthermore, we show that latency ranks exhibit a better reproducibility at the level of M/T cells than in olfactory receptor neurons. Our results suggest that the latency patterns of M/T cells contain all the information higher brain centers need to identify odors and their concentrations.