INHIBITION OF GLUCOSE PHOSPHORYLATION BY MANNOHEPTULOSE
INHIBITION OF GLUCOSE PHOSPHORYLATION BY MANNOHEPTULOSE
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DOI：
10.1042/bj0910056
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发表时间：
1964-01-01
影响因子：
4.1
通讯作者：
RANDLE, PJ
中科院分区：
文献类型：
--
作者：
COORE, HG;RANDLE, PJ
甘露寡糖降低大鼠肝切片对葡萄糖和甘露糖的净摄取量。这一作用归因于抑制肝脏中己糖的磷酸化，因为大鼠肝脏提取物中的甘露七糖对葡萄糖和己糖激酶有抑制作用。文中还讨论了甘露七糖对葡萄糖诱导的胰岛素分泌的抑制作用，也可能与甘露七糖对葡萄糖诱导的胰岛素分泌的抑制作用类似。
Mannoheptu-lose decreased the net uptake of glucose and of mannose by rat-liver slices. This effect was attributed to an inhibition of hexose phosphorylation in the liver because inhibition of glucokinase and hexokinase by mannoheptulose in extracts of rat liver was demonstrated. The possibility that a similar inhibition of glucose phosphorylation in [beta]-cells of isolated rabbit pancreas could contribute to inhibitory effects of mannoheptulose on glucose-induced insulin secretion, observed previously, is discussed.