Studies of calcium and phosphorus metabolism. V. A study of the bone trabeculae as a readily available reserve supply of calcium.
Studies of calcium and phosphorus metabolism. V. A study of the bone trabeculae as a readily available reserve supply of calcium.
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DOI：
10.1084/jem.49.1.145
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发表时间：
1929-01-01
影响因子：
15.3
通讯作者：
Albright, F
中科院分区：
文献类型：
--
作者：
Bauer, W;Aub, JC;Albright, F
甲状旁腺素的长期使用、持续的负钙平衡和生长，使骨小梁容易耗竭。长期持续的高钙饮食导致骨小梁的快速积累。茜素红，如先前在文献中所示，沉积在新形成的骨中。它的使用表明，容易动员的钙不是沉积在成年动物的骨干，但在骨小梁。因此，骨小梁充当容易获得的Ca的仓库。轴有一个缓慢的渐进式交换无机盐和不受影响，除非在不寻常的情况下，身体的需求。提示早产儿骨小梁缺如，4个月后骨小梁耗竭。很可能是佝偻病的一个病因在我们的观察中，甲状旁腺素管理生长或成年猫一直没有效果。每天注射甲状旁腺素会导致生长中的大鼠骨小梁数量增加和骨骼变小。
Bone trabeculae are easily depleted by the prolonged administration of parathormone, long-continued negative Ca balance and growth. A long-continued high Ca diet results in a rapid accumulation of the trabeculae. Alizarin red, as has previously been shown in the literature, is deposited in newly formed bone. Its use has made clear that easily mobilizable Ca is not deposited in the shafts of adult animals, but in the trabeculae of bone. The bone trabeculae therefore serve as the storehouse of readily available Ca. The shafts have a slow progressive exchange of inorganic salts and are not influenced except in the case of unusual body demands. It is suggested that the absence of trabeculae in premature infants and their depletion at the end of 4 mos. in a normal baby might well be an etiological factor in rickets. In our observations, parathormone administration to growing or adult cats has been without effect. Daily injections of parathormone in growing rats results in an increased number of trabeculae and smaller bones.