Prevalence of High-Risk Human Papillomavirus Among Older Women
Prevalence of High-Risk Human Papillomavirus Among Older Women
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DOI：
10.1097/aog.0b013e31818b0df2
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发表时间：
2008-11-01
影响因子：
7.2
通讯作者：
Jordan, Jeanne A.
中科院分区：
文献类型：
--
作者：
Lindau, Stacy Tessler;Drum, Melinda L.;Jordan, Jeanne A.
目的：评估57- 85岁女性高危型人乳头瘤病毒（HPV）的患病率、基因型和个体水平相关性。方法：从全国代表性概率样本中抽取57 -85岁社区居民女性（N= 1，550）。在2005年和2006年之间获得了家庭访谈和生物测量，包括自我收集的阴道标本。使用Hybrid Capture 2分析样本的高危HPV DNA;在提供的1，028份样本中，1，010份足以进行分析。所有检测阳性的样本进行分析HPV DNA的L1共识聚合酶链反应，然后通过类型特异性hybridization.RESULTS：总体人口为基础的加权估计的高危型HPV感染率的混合捕获2（Digene公司）。为6.0%（95%置信区间为4.57.9）。目前的婚姻和吸烟状况，性活动频率，癌症史和子宫切除术与高危HPV阳性相关。在高危HPV阳性妇女中，63%有多种类型的感染。在所有高危HPV阳性妇女中，17.4%存在人乳头瘤病毒-16或-18。高危HPV阳性妇女中最常见的高危基因型是HPV-61（19.1%）、-31（13.1%）、-52（12.9%）、-58（12.5%）、-83（12.3%）、-66（12.0%）、-51（11.7%）、-45（11.2%）、-56（10.3%）、-53（10.2%）、-16（9.7%）和-62（9.2%）。已婚和子宫完整与高危HPV的低患病率独立相关。在未婚妇女中，目前的性活动和吸烟独立和积极相关的高危型HPV infection.CONCLUSION：在这个全国代表性的人口，近1/16的妇女年龄在57-85被发现有高危型HPV，和患病率是稳定的年龄较大的群体。
OBJECTIVE: To estimate the prevalence, genotypes, and individual-level correlates of high-risk human papillomavirus (HPV) among women aged 57-85.METHODS: Community-residing women (N=1,550), aged 57-85, were drawn from a nationally representative probability sample. In-home interviews and biomeasures, including a self-collected vaginal specimen, were obtained between 2005 and 2006. Specimens were analyzed for high-risk HPV DNA using Hybrid Capture 2; of 1,028 specimens provided, 1,010 were adequate for analysis. All samples testing positive were analyzed for HPV DNA by L1 consensus polymerase chain reaction followed by type-specific hybridization.RESULTS: The overall population-based weighted estimate of high-risk HPV prevalence by Hybrid Capture 2 (Digene Corp.) was 6.0% (95% confidence interval 4.57.9). Current marital and smoking status, frequency of sexual activity, history of cancer, and hysterectomy were associated with high-risk HPV positivity. Among high-risk HPV-positive women, 63% had multiple type infections. Human papillomavirus-16 or -18 was present in 17.4% of all high-risk HPV-positive women. The most common high-risk genotypes among high-risk HPV-positive women were HPV-61 (19.1%), -31 (13.1%), -52 (12.9%), -58 (12.5%), -83 (12.3%), -66 (12.0%), -51 (11.7%), -45 (11.2%), -56 (10.3%), -53 (10.2%), -16 (9.7%), and -62 (9.2%). Being married and having an intact uterus were independently associated with lower prevalence of high-risk HPV. Among unmarried women, current sexual activity and smoking were independently and positively associated with high-risk HPV infection.CONCLUSION: In this nationally representative population, nearly 1 in 16 women aged 57-85 was found to have high-risk HPV, and prevalence was stable across older age groups.