Nodular hyperplasia of the liver in primary biliary cirrhosis of early histological stages.
Nodular hyperplasia of the liver in primary biliary cirrhosis of early histological stages.
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原发性胆汁性肝硬化早期组织学阶段的肝脏结节性增生。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
G. Ohta
中科院分区：
文献类型：
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作者：
Y. Nakanuma;G. Ohta
本文回顾了26例原发性胆汁性肝硬化的临床和组织学诊断。无纤维边缘的肝结节增生，迄今未在原发性胆汁性肝硬化患者中报道，在一些早期组织学阶段的患者中发现。这些变化类似于“肝脏结节性再生增生”，通常表现为肝小叶1区和2区多细胞厚度。这类病变多见于食管静脉曲张患者，提示原发性胆汁性肝硬化早期组织学阶段，结节性增生可能与肝内门静脉血流紊乱有关。
Twenty-six patients with the clinical and histologic diagnosis of primary biliary cirrhosis were reviewed. Nodular hyperplasia of the liver without fibrous rims, not reported hitherto in patients with primary biliary cirrhosis, was found in several patients with early histological stages. These changes resembled "nodular regenerative hyperplasia of the liver" and were usually present as multicellular thickness in zones 1 and 2 of the hepatic lobules. Such lesions were preferentially found in patients with esophageal varices, suggesting that the nodular hyperplasia may occur in relation to a disturbance of portal venous blood flow within the liver in primary biliary cirrhosis in early histological stages.