Evidence of major genes for plasma HDL, LDL cholesterol and triglyceride levels at baseline and in response to 20 weeks of endurance training: the HERITAGE Family Study.
Evidence of major genes for plasma HDL, LDL cholesterol and triglyceride levels at baseline and in response to 20 weeks of endurance training: the HERITAGE Family Study.
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基线时血浆 HDL、LDL 胆固醇和甘油三酯水平以及对 20 周耐力训练的反应的主要基因的证据：HERITAGE 家族研究。
DOI：
10.1055/s-2004-821160
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发表时间：
2005
影响因子：
2.5
通讯作者：
Rao,DC
中科院分区：
文献类型：
--
作者：
An,P;Borecki,IB;Rankinen,T;Després,J-P;Leon,AS;Skinner,JS;Wilmore,JH;Bouchard,C;Rao,DC
在传统家庭研究中，这项研究评估了来自99个白人家庭的527个个体和113个黑人家庭的326个个体的基线高密度脂蛋白-C、低密度脂蛋白胆固醇、甘油三酯及其训练反应(训练后减去基线)的主基因效应。在进行遗传分析之前，基线表型根据年龄和BMI的影响进行了调整，训练反应表型根据年龄、BMI及其各自的基线值进行了调整，并按种族进行了逐代性别分析。在白人中，我们发现基线的低密度脂蛋白-C和高密度脂蛋白-C训练反应受到主要隐性基因(解释变异的20%-30%)和多因素(多基因和家族性环境)影响。对这些主基因与性别、年龄和体重指数的交互作用进行了测试，发现它们之间的交互作用并不显著。在黑人中，我们发现基线的高密度脂蛋白-C受到一个主显性基因的影响，而不是多因素成分。这一主基因效应解释了45%的变异，并且与年龄、性别和BMI没有表现出显著的特定于基因型的交互作用。在两个种族中都没有发现基线和耐力训练反应的其余表型的主基因的证据，尽管一些受到不符合孟德尔预期的主效应的影响，或者是从父母传给后代的模糊遗传。综上所述，本研究检测了影响基线血浆高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平的主要基因效应，以及有规律运动后高密度脂蛋白胆固醇水平的变化。
This study assessed major gene effects for baseline HDL-C, LDL-C, TG, and their training responses (post-training minus baseline) in 527 individuals from 99 White families and 326 individuals from 113 Black families in the HERITAGE Family Study. The baseline phenotypes were adjusted for the effects of age and BMI, and the training response phenotypes were adjusted for the effects of age, BMI, and their respective baseline values, within each of the sex-by-generation-by-race groups, prior to genetic analyses. In Whites, we found that LDL-C at baseline and HDL-C training response were under influence of major recessive genes (accounting for 20-30% of the variance) and multifactorial (polygenic and familial environmental) effects. Interactions of these major genes with sex, age, and BMI were tested, and found to be nonsignificant. In Blacks, we found that baseline HDL-C was influenced by a major dominant gene without a multifactorial component. This major gene effect accounted for 45% of the variance, and exhibited no significant genotype-specific interactions with age, sex, and BMI. Evidence of major genes for the remaining phenotypes at baseline and in response to endurance training were not found in both races, though some were influenced by major effects that did not follow Mendelian expectations or were with ambiguous transmission from parents to offspring. In summary, major gene effects that influence baseline plasma HDL-C and LDL-C levels as well as changes in HDL-C levels in response to regular exercise were detected in the current study.