Pathology of Vogt-Koyanagi-Harada disease
Pathology of Vogt-Koyanagi-Harada disease
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DOI：
10.1007/s10792-006-9029-2
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发表时间：
2007-06-01
影响因子：
1.6
通讯作者：
Rao, Narsing A.
中科院分区：
文献类型：
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作者：
Rao, Narsing A.
Vogt-Koyanagi-Harada病（VKH）的典型组织病理学特征包括肉芽肿性全葡萄膜炎并保留脉络膜毛细血管和渗出性视网膜脱离。然而，在疾病的慢性期，组织学变化包括非肉芽肿性葡萄膜炎，随后在慢性复发期，肉芽肿性葡萄膜炎和绒毛膜毛细血管受累。慢性VKH的周围性眼底瘢痕不是Dalen-Fuchs结节；相反，它们表明局灶性绒毛膜视网膜萎缩伴视网膜色素上皮的丧失。
Typical histopathologic features of Vogt-Koyanagi-Harada disease (VKH) include granulomatous panuveitis with preservation of the choriocapillaris and exudative retinal detachment. In the chronic stage of the disease, however, histologic changes consist of nongranulomatous uveitis followed, in the chronic recurrent stage, by granulomatous uveitis and involvement of the choriocapillaris. In chronic VKH the peripheral fundus scars are not Dalen-Fuchs nodules; they are, instead, indicative of focal chorioretinal atrophy with loss of retinal pigment epithelium.