Prevalence of atherosclerotic plaque in young and middle-aged asymptomatic individuals: the Bogalusa heart study.
Prevalence of atherosclerotic plaque in young and middle-aged asymptomatic individuals: the Bogalusa heart study.
复制标题
年轻和中年无症状个体中动脉粥样硬化斑块的患病率：Bogalusa 心脏研究。
DOI：
10.1097/smj.0b013e318236c35c
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发表时间：
2011
影响因子：
1.1
通讯作者：
Berenson,GeraldS
中科院分区：
文献类型：
--
作者：
Kelley,RogerEverett;Dasmahapatra,Pronabesh;Wang,Jian;Chen,Wei;Srinivasan,SathanurR;Fernandez,Camilo;Xu,Jihua;Martin-Schild,Sheryl;Berenson,GeraldS
目的了解29 ~ 51岁社区无症状非裔美国人和白人男性和女性颈动脉和股动脉粥样硬化斑块的患病率及其与心血管危险因素的潜在关系。方法2007年至2010年间，914名受试者，其中58%为女性，69%为白人，这些受试者是Bogalusa心脏研究的一部分，该研究是路易斯安那州Bogalusa南部混血儿社区的一项正在进行的研究，从童年到成年，使用超声波评估斑块形成情况。在所有受试者中，排除有心/脑血管事件史的受试者。结果斑的患病率在8% ~ 14%之间，白人男性患病率较高。斑块的形成也与吸烟、高血压、糖尿病、年龄和白种人有关。结论：自1973年以来对这一人群进行的连续研究表明，斑块的存在与公认的心血管危险因素相关，尽管我们没有发现肥胖或血脂升高（包括低密度脂蛋白胆固醇）的显著影响。干预措施，如饮食改变和他汀类药物治疗，可能对这些潜在的斑块形成因素产生积极影响，高血压、糖尿病和吸烟仍然非常重要。
ObjectivesTo determine the prevalence of carotid and femoral artery atherosclerotic plaque in a community-based population of asymptomatic African American and white men and women, with an age range of 29 to 51 years, and the potential relations with cardiovascular risk factors.MethodsBetween 2007 and 2010, 914 subjects, 58% women and 69% white, who were part of the Bogalusa Heart Study, an ongoing study of a southern biracial community in Bogalusa, Louisiana, were followed up from childhood through adulthood and assessed for plaque formation using ultrasound. Of the total number of subjects, those with a history of cardiovascular/cerebrovascular events were excluded.ResultsPlaque prevalence ranged from 8% to 14%, with greater frequency in white men. Plaque formation was also associated with smoking, hypertension, diabetes mellitus, age, and white race, in descending order.ConclusionsIn this population, studied sequentially since 1973, the presence of plaque correlated with widely recognized cardiovascular risk factors, although we did not detect significant contributions from either obesity or elevated lipids, including low-density lipoprotein cholesterol. It is possible that interventions, such as diet alteration and statin therapy, may have a positive impact on these potential contributors to plaque formation, and hypertension, diabetes mellitus and smoking remain of great importance.