MODIFICATION OF SIDE CHAIN OF FUSIDIC ACID (RAMYCIN)
MODIFICATION OF SIDE CHAIN OF FUSIDIC ACID (RAMYCIN)
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DOI：
10.1021/jm00314a016
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发表时间：
1967-01-01
影响因子：
7.3
通讯作者：
VANDERHA.H
中科院分区：
文献类型：
--
作者：
JANSSEN, G;VANDERHA.H
用等摩尔量的臭氧处理夫西地酸产生24-醛2a和少量的17-酮10。通过转化成腈7，证实了醛2a的结构。2a的醛官能被还原为醇8，也转化为甲基，即化合物9。测定了这些产物及其衍生物的抑菌活性。
Treatment of fusidic acid with an equimolar amount of ozone produced the 24-aldehyde 2a and a small amount of the 17-ketone 10. The structure of the aldehyde 2a was proved by transformation into a nitrile 7. The aldehyde function of 2a was reduced to an alcohol 8 and was also converted into a methyl group, compound 9. The antibacterial activities of these products and of some derivatives were determined.