Role of presynaptic glutamate receptors in pain transmission at the spinal cord level.
Role of presynaptic glutamate receptors in pain transmission at the spinal cord level.
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DOI：
10.2174/1570159x11311050002
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发表时间：
2013-09
影响因子：
5.3
通讯作者：
Bardoni R
中科院分区：
文献类型：
--
作者：
Bardoni R
伤害性初级传入神经释放谷氨酸，激活脊髓背角神经元上的突触后谷氨酸受体。谷氨酸受体（离子型和代谢型）也在突触前末梢表达，调节神经递质的释放。在过去的二十年中，大量研究描述了突触前谷氨酸受体的特性，特别是那些在初级传入纤维上表达的受体。本综述描述了啮齿动物脊髓背角表达的突触前谷氨酸离子型受体（AMPA、NMDA、红藻氨酸）和代谢型受体的亚基组成、分布和功能。还将讨论突触前受体在急性和慢性疼痛实验模型中调节伤害性信息的作用。
Nociceptive primary afferents release glutamate, activating postsynaptic glutamate receptors on spinal cord dorsal horn neurons. Glutamate receptors, both ionotropic and metabotropic, are also expressed on presynaptic terminals, where they regulate neurotransmitter release. During the last two decades, a wide number of studies have characterized the properties of presynaptic glutamatergic receptors, particularly those expressed on primary afferent fibers. This review describes the subunit composition, distribution and function of presynaptic glutamate ionotropic (AMPA, NMDA, kainate) and metabotropic receptors expressed in rodent spinal cord dorsal horn. The role of presynaptic receptors in modulating nociceptive information in experimental models of acute and chronic pain will be also discussed.