Protein dynamical transition in terahertz dielectric response
Protein dynamical transition in terahertz dielectric response
复制标题
DOI：
10.1016/j.cplett.2007.05.080
复制
发表时间：
2007-07-17
影响因子：
2.8
通讯作者：
He, Yunfen
中科院分区：
文献类型：
--
作者：
Markelz, Andrea G.;Knab, Joseph R.;He, Yunfen
在太赫兹介电响应中首次观察到200 K蛋白质动力学跃迁。在0.2-2.0 THz和80-294 K范围内确定了复介电常数ε = ε ′ + ε ′。在200 K以下，“ε”具有线性温度依赖性，然后急剧增加。0的低温线性依赖性表明温度80 K < T < 180 K时存在非谐性，挑战了200 K以下的假设谐性。的温度依赖性是一致的热激活侧链运动，并显示在动态过渡延伸到亚皮秒的时间尺度所涉及的运动。(c)2007 Elsevier B. V.保留所有权利。
The 200 K protein dynamical transition is observed for the first time in the terahertz dielectric response. The complex dielectric permittivity epsilon = epsilon' + i epsilon' is determined in the 0.2-2.0 THz and 80-294 K ranges. epsilon" has a linear temperature dependence up to 200 K then sharply increases. The low temperature linear dependence in 0 suggests anharmonicity for temperatures 80 K < T < 180 K, challenging the assumed harmonicity below 200 K. The temperature dependence is consistent with thermally activated sidechain motions and shows the motions involved in the dynamical transition extend to subpicosecond time scales. (c) 2007 Elsevier B.V. All rights reserved.