Core-shell ZIF-8@polydopamine nanoparticles obtained by mitigating the polydopamine coating induced self-etching of MOFs: prototypical metal ion reservoirs for sticking to and killing bacteria
Core-shell ZIF-8@polydopamine nanoparticles obtained by mitigating the polydopamine coating induced self-etching of MOFs: prototypical metal ion reservoirs for sticking to and killing bacteria
复制标题
通过减轻聚多巴胺涂层诱导的MOF自蚀刻而获得的核壳ZIF-8@聚多巴胺纳米粒子：用于粘附和杀死细菌的原型金属离子库
DOI：
10.1039/d1nj00461a
复制
发表时间：
2021-04-09
影响因子：
3.3
通讯作者：
Zhang, Zhenkun
中科院分区：
文献类型：
--
作者：
Tu, Yingxue;Lei, Caifen;Zhang, Zhenkun
金属有机框架（MOFs）有可能促进金属离子被低估的生物医学应用。这样的奋进已经受到如何避免过早释放的金属离子对健康细胞或生物体的（细胞）毒性以及在实现靶向应用之前与生物流体中的组分形成的离子的无定形沉淀物的挑战的阻碍。目前的工作旨在通过开发原型金属离子库来部分解决这些挑战。我们制备了定义明确的核-壳ZIF-8@PDA纳米粒子，其中沸石咪唑酯骨架-8（ZIF-8）作为Zn 2+的储库，聚多巴胺（PDA）作为壳，具有固有的金属离子螯合能力。通过控制立方ZIF-8纳米颗粒的表面性质，减轻了聚多巴胺涂层上的MOF模板的众所周知的自蚀刻问题。由于受到PDA外壳的调节，可以部分捕获过早释放的金属离子，ZIF-8@PDA纳米颗粒具有独特的Zn 2+释放行为，包括有限释放阶段，然后是pH依赖性的突发释放，可以迅速将局部Zn 2+浓度增加到有害水平。证明了ZIF-8@PDA对革兰氏阳性金黄色葡萄球菌的抗菌效率增强。这可能归因于ZIF-8@PDA与细菌的强相互作用，如PDA的固有生物粘附所驱动的，这可以通过避免潜在的沉淀来促进释放的锌离子与细菌的直接相互作用。
Metal-organic frameworks (MOFs) have the potential to boost the undervalued biomedical applications of metal ions. Such endeavor has been hindered by the challenge of how to avoid the (cyto)toxicity of the prematurely released metal ions to healthy cells or organisms and amorphous precipitates of ions formed with components in biological fluids before achieving targeting applications. The current work aimed to partially address such challenges by developing a prototypical metal ion reservoir. We prepared well-defined core-shell ZIF-8@PDA nanoparticles, with zeolitic imidazolate framework-8 (ZIF-8) as the reservoir of Zn2+ and polydopamine (PDA) with inherent metal ion chelating capabilities as the shell. The well-known self-etching problem of MOF templates upon polydopamine coating was mitigated by controlling the surface properties of cubic ZIF-8 nanoparticles. As regulated by the PDA shell that can partially trap the prematurely released metal ions, ZIF-8@PDA nanoparticles had a unique Zn2+ releasing behavior consisting of a limited releasing stage followed by pH-dependent burst releasing that could quickly increase the local Zn2+ concentration to harmful levels. Enhanced antibacterial efficiency of ZIF-8@PDA against Gram-positive Staphylococcus aureus was demonstrated. This could be attributed to the strong interaction of ZIF-8@PDA with bacteria as driven by inherent bioadhesion of PDA, which could promote direct interactions of released zinc ions with bacteria by avoiding potential precipitations.