Epidemiology of sarcoidosis in Japan
Epidemiology of sarcoidosis in Japan
复制标题
DOI：
10.1183/09031936.00075307
复制
发表时间：
2008-02-01
影响因子：
24.3
通讯作者：
Nukiwa, T.
中科院分区：
文献类型：
--
作者：
Morimoto, T.;Azuma, A.;Nukiwa, T.
本研究旨在利用全国流行病学调查来确定近期的临床表型，并将结果与日本之前的调查结果进行比较。2004 年新诊断的病理学确诊的结节病病例符合本研究的条件。记录并比较疾病参数。总共招募了 1,027 名患者，该群体占整个日本人口的 79.4%。研究参与者包括 364 名男性和 663 名女性，平均发病率为每 10 万居民 1.01 例（男性 0.73 例，女性 1.28 例）。整个患者群体和女性的年龄特异性发病率呈现出双相模式。男性发病率在20-34岁群体中达到高峰。 50-60 岁女性的第二个峰值显示出比第一个年轻峰值更高的发病率。眼睛、皮肤和心脏实验室检查结果异常的患者分别占病例的54.8%、35.4%和23.0%。与日本以往的调查相比，女性/男性的发病率有所增加，眼睛和皮肤受累以及心脏异常的频率也较高。 总之，本研究获得的数据与其他国家的数据不同，与日本以往的研究相比，结节病临床表型发生了变化。
The present study was designed to identify recent clinical phenotypes using the National Epidemiological Survey and to compare findings with those of previous surveys in Japan.Pathologically confirmed sarcoidosis cases newly diagnosed in 2004 were eligible for the present study. Disease parameters were recorded and compared.A total of 1,027 patients were enrolled from a cluster encompassing 79.4% of the entire Japanese population. The study participants consisted of 364 males and 663 females, providing an average incidence rate of 1.01 per 100,000 inhabitants (0.73 for males and 1.28 for females). The age-specific incidence rate displayed a biphasic pattern in the whole patient population and in the females. The male incidence rates peaked in the 20-34-yr-old group. A second peak for 50-60-yr-old females showed a higher incidence than the first younger peak. Patients with abnormalities in eyes, skin and cardiac laboratory findings accounted for 54.8, 35.4 and 23.0% of cases, respectively. The female/male incidence ratio was increased, and the frequency of eye and skin involvement and cardiac abnormality was higher than in previous surveys conducted in Japan.In conclusion, the data obtained in the present study differ from those of other countries and showed changes in sarcoidosis clinical phenotypes compared with previous studies in Japan.