Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
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DOI：
10.1016/j.pscychresns.2010.06.009
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发表时间：
2010-09-30
影响因子：
2.3
通讯作者：
Lawrie, Stephen M.
中科院分区：
文献类型：
--
作者：
Baig, Benjamin J.;Whalley, Heather C.;Lawrie, Stephen M.
多种证据表明脑源性神经营养因子（BDNF）在精神分裂症的病理生理学中的作用。然而，目前尚不清楚BDNF如何影响这种疾病或高遗传风险患者的脑功能改变。目前的研究探讨了精神分裂症高遗传风险人群中BDNF val 66 met多态性的功能成像相关性。在高遗传风险的障碍（n = 58）提供BDNF基因分型和功能磁共振成像数据，同时执行文字记忆任务的主题。在编码过程中，参与者被呈现一个单词，并被要求进行“生命”/“非生命”分类。在检索过程中，个人被要求进行“旧”/“新”字分类。对于编码，我们报告减少激活的枕叶下皮质和扣带皮质的趋势在瓦尔纯合子个体相对于Met载体。对于检索，我们报告减少激活的前额叶，扣带皮层和双侧后顶叶区域的瓦尔纯合子个体与Met载体。这些发现增加了先前的证据，表明BDNF基因的遗传变异调节了前额叶和边缘系统的功能，并表明它可能有助于在高风险人群中观察到的大脑功能差异。(c)2010爱思唯尔爱尔兰有限公司版权所有。
Multiple strands of evidence suggest a role for Brain Derived Neurotrophic Factor (BDNF) in the pathophysiology of schizophrenia. It is not yet clear, however, how BDNF may contribute to altered brain function seen in the disorder, or in those at high genetic risk. The current study examines functional imaging correlates of the BDNF val66met polymorphism in a population at high genetic risk of schizophrenia. Subjects at high genetic risk for the disorder (n = 58) provided both BDNF genotyping and fMRI data while performing a verbal memory task. During encoding, participants were presented with a word and asked to make a 'living'/'non-living' classification. During retrieval, individuals were requested to make an 'old'/'new' word classification. For encoding, we report decreased activation of the inferior occipital cortex and a trend in the cingulate cortex in Val homozygote individuals relative to Met carriers. For retrieval, we report decreases in activation in the prefrontal, cingulate cortex and bilateral posterior parietal regions in Val homozygote individuals versus Met carriers. These findings add to previous evidence suggesting that genetic variation in the BDNF gene modulates prefrontal and limbic functioning and suggests that it may contribute to differences in brain function seen in those at high risk of the disorder. (c) 2010 Elsevier Ireland Ltd. All rights reserved.