Fabrication of micro-gas chromatograph columns for fast chromatography
Fabrication of micro-gas chromatograph columns for fast chromatography
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DOI：
10.1007/s00542-006-0210-3
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发表时间：
2007-02-01
影响因子：
2.1
通讯作者：
Goettert, Jost
中科院分区：
文献类型：
--
作者：
Bhushan, Abhinav;Yemane, Dawit;Goettert, Jost
气相色谱法（GC）是实验室中最广泛使用的技术之一，用于分离和分析挥发性和半挥发性化合物的复杂混合物。这些系统小型化的主要优点是由于减少了分析时间和降低了复杂气动流动系统的制造成本而提高了性能。在本文中，先进的设计思想和制造工艺，以促进集成的样品浓缩器和柱将被提出。使用LIGA工艺，0.5-和2-m长，50-μ m宽，高达600-μ m高的纵横比金属GC分离柱与芯片集成的样品注入和检测。与简单的管状柱相比，涂覆这些高纵横比柱的初始实验显示出有希望的结果。
Gas chromatography (GC) is one of the most widespread techniques used in laboratories as a way to separate and analyze complex mixtures of volatile and semi-volatile compounds. The main advantage of miniaturization of these systems is the increased performance due to the reduced time for analysis and reduced fabrication cost of the complex pneumatic flow system. In this paper advanced design ideas and fabrication processes to facilitate integration of the sample concentrator and the column will be presented. Using the LIGA process, 0.5- and 2-m-long, 50-mu m-wide, and up to 600-mu m-high aspect ratio metal GC separation columns with on-chip integrated sample injection and detection were fabricated. Initial experiments of coating these high aspect ratio columns show promising results when compared to simple tubular columns.