ORGANIZATION OF THE EFFERENT PROJECTIONS OF THE NUCLEUS ACCUMBENS TO PALLIDAL, HYPOTHALAMIC, AND MESENCEPHALIC STRUCTURES - A TRACING AND IMMUNOHISTOCHEMICAL STUDY IN THE CAT
ORGANIZATION OF THE EFFERENT PROJECTIONS OF THE NUCLEUS ACCUMBENS TO PALLIDAL, HYPOTHALAMIC, AND MESENCEPHALIC STRUCTURES - A TRACING AND IMMUNOHISTOCHEMICAL STUDY IN THE CAT
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DOI：
10.1002/cne.902230303
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
RUSSCHEN, FT
中科院分区：
文献类型：
--
作者：
GROENEWEGEN, HJ;RUSSCHEN, FT
利用顺行和逆行追踪技术研究了猫伏隔核的传出连接。在描述这些向苍白球、下丘脑和中脑区域的投射的分布之前，利用免疫组织化学标准重新界定了猫苍白球区域的边界。与先前在大鼠和猴子中的研究一致，猫苍白球中类P物质和类脑啡肽免疫反应似乎存在于所谓的绒毛纤维中。类P物质和脑啡肽阳性的绒毛纤维在传统定义的苍白球内侧部和外侧部呈差异性分布，但都存在于无名质的吻侧部，在此称为腹侧苍白球。绒毛纤维还在许多其他基底端脑结构以及下丘脑外侧区的吻侧部被发现。伏隔核内侧部的纤维分布到腹侧苍白球以及下丘脑外侧区吻侧部上述区域，该区域很可能代表苍白球内侧部的一部分。伏隔核内侧部除投射到外侧隔、终纹床核、内侧视前区和下丘脑区、腹侧被盖区、红核后核、中央上核、脚桥被盖核和中央灰质外，还投射到其他区域。伏隔核外侧部投射到腹侧苍白球、苍白球连合下部分、内苍白球、黑质和红核后核。
The efferent connections of the nucleus accumbens in the cat were studied with the aid of anterograde and retrograde tracing techniques. The description of the topography of these projections to pallidal, hypothalamic and mesencephalic areas is preceded by a redefinition of the borders of the pallidal regions in the cat, using immunohistochemical criteria. In agreement with previous studies in rat and monkey substance-P-like and enkephalin-like immunoreactivity in the pallidum of the cat appears to be present in so-called woolly fibers. Substance-P- and enkephalin-positive woolly fibers are differentially distributed in the internal and external segments of the globus pallidus, as traditionally defined, but are both present in the rostral part of the substantia innominata, here called the ventral pallidum. Woolly fibers are also found in a number of other basal telencephalic structures and in the rostral part of the lateral hypothalamic area. Fibers from the medial part of the nucleus accumbens distribute to the ventral pallidum and to the just-mentioned area in the rostral part of the lateral hypothalamus, which most probably represents part of the internal segment of the globus pallidus. The medial nucleus accumbens projects in addition to the lateral septum, the bed nucleus of the stria terminalis, the medial preoptic and hypothalamic areas, the ventral tegmental area, the retrorubral nucleus, the central superior nucleus, the nucleus tegmenti pedunculopontinus and the central gray. The lateral part of the nucleus accumbens projects to the ventral pallidum, the subcommissural part of the globus pallidus, the entopeduncular nucleus, the substantia nigra, and the retrorubral nucleus.