Characterization of the temporo-parietal junction by combining data-driven parcellation, complementary connectivity analyses, and functional decoding.
Characterization of the temporo-parietal junction by combining data-driven parcellation, complementary connectivity analyses, and functional decoding.
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DOI：
10.1016/j.neuroimage.2013.05.046
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发表时间：
2013-11-01
期刊：
影响因子：
5.7
通讯作者：
Eickhoff SB
中科院分区：
文献类型：
--
作者：
Bzdok D;Langner R;Schilbach L;Jakobs O;Roski C;Caspers S;Laird AR;Fox PT;Zilles K;Eickhoff SB
右颞顶叶交界处（RTPJ）一直涉及两个认知领域，注意力和社会认知。我们进行了多模态的连接性为基础的parcellation调查潜在的独立功能模块在RTPJ实现这种认知二元论。任务约束的元分析共激活映射和无任务的休息状态连接分析独立地确定了两个不同的集群内RTPJ，随后其特征在于网络映射和功能正向/反向推理。共激活映射和休息状态的相关性表明，前集群增加神经活动伴随着一个中扣带运动岛网络，功能与注意力，并减少神经活动伴随着顶叶网络，功能与社会认知和记忆检索。后集群显示出完全相反的关联模式。因此，我们的数据表明，RTPJ连接两个对立的大脑网络处理外部和内部信息。
The right temporo-parietal junction (RTPJ) is consistently implicated in two cognitive domains, attention and social cognitions. We conducted multi-modal connectivity-based parcellation to investigate potentially separate functional modules within RTPJ implementing this cognitive dualism. Both task-constrained meta-analytic coactivation mapping and task-free resting-state connectivity analysis independently identified two distinct clusters within RTPJ, subsequently characterized by network mapping and functional forward/reverse inference. Coactivation mapping and resting-state correlations revealed that the anterior cluster increased neural activity concomitantly with a midcingulate–motor–insular network, functionally associated with attention, and decreased neural activity concomitantly with a parietal network, functionally associated with social cognition and memory retrieval. The posterior cluster showed the exact opposite association pattern. Our data thus suggest that RTPJ links two antagonistic brain networks processing external versus internal information.