Telomeres and human somatic fitness
Telomeres and human somatic fitness
复制标题
DOI：
10.1093/gerona/61.8.871
复制
发表时间：
2006-08-01
影响因子：
5.1
通讯作者：
Aviv, Abraham
中科院分区：
文献类型：
--
作者：
Aviv, Abraham
平均白细胞端粒长度可能是生物学年龄的指标，因此，它似乎提供了超过实际年龄的信息，以了解人类发生衰老疾病的风险。在这里，我建议，平均白细胞端粒长度是一个指数的“躯体健康”，一个概念，打破了老化和老化疾病之间的人为界限。我还提出，在特别老的人中，超短的白细胞端粒可能是寿命的决定因素。
Mean leukocyte telomere length may be an indicator of biological age, and as such it appears to provide information over and above chronological age of the risk for developing diseases of aging in humans. Here I propose that the mean leukocyte telomere length is an index of "somatic fitness," a concept that breaks down the artificial boundary between aging and diseases of aging. I also propose that, in exceptionally old humans, ultrashort leukocyte telomeres might be a determinant of life span.