Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines
Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines
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DOI：
10.1021/acs.orglett.5b01057
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发表时间：
2015-06-19
期刊：
影响因子：
5.2
通讯作者：
Cui, Sheng
中科院分区：
文献类型：
--
作者：
Chen, Ying;Huang, Jinkun;Cui, Sheng
报道了一种温和条件下不对称吡啶氮氧化物的高效区域选择性卤代反应。该方法提供了一个实际的访问各种2-卤代吡啶，这是重要的医药中间体。
A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.