Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia
Changes in Nicotinic and Muscarinic Cholinergic Receptors in Alzheimer‐Type Dementia
复制标题
阿尔茨海默型痴呆中烟碱和毒蕈碱胆碱能受体的变化
DOI：
10.1111/j.1471-4159.1986.tb12960.x
复制
发表时间：
1986
影响因子：
4.7
通讯作者：
Masakuni Kameyama
中科院分区：
文献类型：
--
作者：
S. Shimohama;T. Taniguchi;M. Fujiwara;Masakuni Kameyama
摘要：采用配体结合技术，研究了4例组织学正常对照和5例组织病理学证实的阿尔茨海默型痴呆（ATD）病例尸检脑中的烟碱和毒蕈碱胆碱能受体。分别通过（-）-[3 H]尼古丁和[3 H]奎宁环二苯乙酸酯（[3 H]QNB）评估尼古丁和毒蕈碱胆碱能受体。与对照组相比，在壳核和Meynert基底核（NbM）中，检查的ATD脑区域中的（-）-[3 H]尼古丁结合位点显著减少。[3 H]QNB结合在海马和NbM中显著降低。这些结果表明，有显着的变化，烟碱和毒蕈碱胆碱能受体在选定区域的ATD的大脑。
Abstract: Nicotinic and muscarinic cholinergic receptors were studied in autopsied brains from four histologically normal controls and five histopathologically verified cases of Alzheimer‐type dementia (ATD), using ligand binding techniques. Nicotinic and muscarinic cholinergic receptors were assessed by (–)‐[3H]nicotine and [3H]quinuclidinyl benzilate ([3H]QNB), respectively. Compared with the controls, (–)‐[3H]nicotine binding sites in the ATD brain regions examined were significantly reduced in the putamen and the nucleus basalis of Meynert (NbM). [3H]QNB binding was significantly reduced in the hippocampus and NbM. These findings suggest that there are significant changes of nicotinic and muscarinic cholinergic receptors in selected regions of ATD brains.