Hormonal control of rates of metamorphic development in the tobacco hornworm Manduca sexta.
Hormonal control of rates of metamorphic development in the tobacco hornworm Manduca sexta.
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DOI：
10.1016/0012-1606(83)90257-9
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发表时间：
1983-09
影响因子：
2.7
通讯作者：
L. Schwartz;J. Truman
中科院分区：
文献类型：
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作者：
L. Schwartz;J. Truman
manduca的变态率似乎受到体外类固醇循环滴度的持续调节。蜕皮甾体在成体分化的前三分之一阶段促进发育。我们在这里提出了几条线的证据表明，在成年分化的后期阶段，蜕皮激素的作用转变为抑制作用。腹部结扎术会急剧降低腹部的类固醇激素水平，从而加快该区域的组织发育速度。这种加速可以通过注射外甾体或植入前胸腺来抵消。向发育后期的昆虫输注蜕皮激素会导致随后发育速率的剂量依赖性抑制。给定剂量类固醇的有效性取决于发育阶段，年龄较大的动物受到的影响更大。最后，正常的体外类固醇滴度在发育的最后3天逐步下降，这些步骤与腹部结扎术在同一时期的有效性下降是平行的。由此得出结论，体外甾体激素在发育后期的作用提供了一种机制，以确保昆虫的各种组织以协调的方式完成变态。
The rate of metamorphosis inManducaappears to be under continuous regulation by the circulating titer of the ecdysteroids. Ecdysteroids promote development during the first third of adult differentiation. We present here several lines of evidence indicating that the role of the ecdysteroids then changes to being inhibitory during the later stages of adult differentiation. Abdomen ligation, which precipitously reduces the levels of ecdysteroids in the abdomen, accelerates the rates of tissue development in this region. This acceleration can be counteracted by ecdysteroid injection or by implantation of prothoracic glands. Infusion of ecdysteroids into insects late in development results in a dose-dependent depression in the rate of subsequent development. The effectiveness of a given dosage of steroid is dependent on the developmental stage, with older animals being more affected. Last, the normal ecdysteroid titer declines in a stepwise fashion over the last 3 days of development and these steps are paralleled by a drop-off in the effectiveness of abdomen ligation over this same period. It is concluded that this effect of the ecdysteroids late in development provides a mechanism to ensure that the various tissues of the insect complete metamorphosis in a coordinated fashion.