Age- and Sex-Graded Data Evaluation of Vaccination Reactions after Initial Injection of the BNT162b2 mRNA Vaccine in a Local Vaccination Center in Germany.
Age- and Sex-Graded Data Evaluation of Vaccination Reactions after Initial Injection of the BNT162b2 mRNA Vaccine in a Local Vaccination Center in Germany.
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DOI：
10.3390/vaccines9080911
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发表时间：
2021-08-16
期刊：
影响因子：
7.8
通讯作者：
Plachter B
中科院分区：
文献类型：
--
作者：
Hoffmann MA;Wieler HJ;Enders P;Buchholz HG;Plachter B
老年人和特别是慢性病患者对2019冠状病毒病（COVID-19）的高疫苗接种率可能是遏制大流行的最重要因素之一。2020年12月德国启动疫苗接种工作时，最初是从年龄较大的人群开始进行疫苗接种优先排序。回顾性检查了1065名在三周前接受第一剂来自BioNTech/Pfizer的信使核糖核酸（mRNA）疫苗BNT 162 b2 Tozinameran的个体的副作用率。年龄和性别分级数据分析显示，在疫苗相关不良反应方面存在明显的年龄和性别差异。在所有80岁以上的人群中，77%的人在首次接种疫苗后没有出现局部或全身副作用，而在80岁以下的人群中，只有37%的人没有出现副作用。在整个研究人群中，64%的女性和73%的男性报告没有出现不良反应。用mRNA疫苗BNT 162 b2的初始接种显示出总体低的副作用特征。特别是在那些超过80年，一个非常好的耐受性与同样良好的效果是显而易见的。性别比较表明，妇女更容易发生疫苗接种不良反应。为了获得足够的群体免疫力，在未来的疫苗接种策略中应考虑年龄和性别依赖性疫苗接种反应以及免疫力维持方面的任何差异。
A high vaccination rate of older and particularly chronically ill people against coronavirus disease-2019 (COVID-19) is likely one of the most important factors in containing the pandemic. When Germany’s vaccination campaign started on December 2020, vaccination prioritization was initially carried out starting with older population groups. Side effect rates in 1065 individuals who had received the first dose of the messenger ribonucleic acid (mRNA) vaccine BNT162b2 Tozinameran from BioNTech/Pfizer three weeks earlier were examined retrospectively. An age- and gender-graded data analysis showed clear age and gender differences with regard to vaccine-related adverse effects. In 77% of all individuals over 80 years of age, no local or systemic side effects were reported after the first vaccination, whereas in the age group up to 80 years, only 37% showed no side effects. In the whole study population, 64% of females and 73% of males reported no adverse effects. The initial vaccination with mRNA vaccine BNT162b2 shows an overall low profile of side effects. Particularly in those over 80 years, an extraordinarily good tolerance with equally good effectiveness is evident. The sex comparison showed that women suffer more often from adverse vaccination reactions. In order to achieve sufficient herd immunity, both age- and gender-dependent vaccination reactions and any difference in the maintenance of immunity should be considered in future vaccination strategies.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1016/s0140-6736(21)00677-2
发表时间：
2021-05-01
期刊：
Lancet (London, England)
影响因子：
--
作者：
Vasileiou E;Simpson CR;Shi T;Kerr S;Agrawal U;Akbari A;Bedston S;Beggs J;Bradley D;Chuter A;de Lusignan S;Docherty AB;Ford D;Hobbs FR;Joy M;Katikireddi SV;Marple J;McCowan C;McGagh D;McMenamin J;Moore E;Murray JL;Pan J;Ritchie L;Shah SA;Stock S;Torabi F;Tsang RS;Wood R;Woolhouse M;Robertson C;Sheikh A
通讯作者：
Sheikh A
影响因子：
9.2
作者：
Potluri, Tanvi;Fink, Ashley L.;Klein, Sabra L.
通讯作者：
Klein, Sabra L.
影响因子：
5.5
作者：
Abu Mouch S;Roguin A;Hellou E;Ishai A;Shoshan U;Mahamid L;Zoabi M;Aisman M;Goldschmid N;Berar Yanay N
通讯作者：
Berar Yanay N
影响因子：
7.8
作者：
Nittner-Marszalska M;Rosiek-Biegus M;Kopeć A;Pawłowicz R;Kosińska M;Łata A;Szenborn L
通讯作者：
Szenborn L