A Structural Perspective on the Where, How, Why, and What of Nucleosome Positioning
A Structural Perspective on the Where, How, Why, and What of Nucleosome Positioning
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DOI：
10.1080/07391102.2010.10508585
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发表时间：
2010-06-01
影响因子：
4.4
通讯作者：
Grigoryev, Sergei A.
中科院分区：
文献类型：
--
作者：
Arya, Gaurav;Maitra, Arijit;Grigoryev, Sergei A.
真核生物染色质中的DNA被组蛋白包装成称为核小体的重复单元阵列。每个核小体包含一个核小体核心，其中DNA包裹在组蛋白八聚体周围，以及一段相对不受约束的DNA，称为接头DNA。由于核小体核心包合了许多DNA结合因子的DNA，它们的位置为理解染色质包装和基因调控提供了重要线索。在这里，我们回顾了核小体位置的全基因组定位的最新进展，核小体定位的分子和结构决定因素，以及核小体定位在染色质高阶折叠和转录调控中的重要性。
The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation.