aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.
aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.
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AIR-1，一个新发现的小鼠染色体16上的基因座，编码用于MHC II类基因表达的反式活化因子因子。
DOI：
10.1084/jem.164.1.369
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发表时间：
1986-07-01
影响因子：
15.3
通讯作者：
Guardiola, J
中科院分区：
文献类型：
--
作者：
Accolla, R S;Jotterand-Bellomo, M;Scarpellino, L;Maffei, A;Carra, G;Guardiola, J
RJ 2.2.5是一种人类B细胞株，已失去表达MHC II类基因的能力。在RJ 2.2.5和小鼠脾细胞之间的体细胞杂交中恢复了人类II类阳性表型。通过对一个信息丰富的杂交种家族的核型和分子研究，我们现在已经表明，人类II类基因产物的重新表达以及小鼠II类阳性表型的维持与小鼠16号染色体的存在有关。因此，在这条小鼠染色体上存在一个新发现的座位，由我们AIR-1指定，它决定了II类基因表达的反式激活功能。本文还讨论了这一发现的可能影响。
RJ 2.2.5 is a human B cell line that has lost the capacity to express MHC class II genes. The human class II-positive phenotype is restored in somatic cell hybrids between RJ 2.2.5 and mouse spleen cells. By karyotype and molecular studies of an informative family of hybrids we have now shown that the reexpression of human class II gene products, as well as the maintenance of the mouse class II-positive phenotype, correlates with the presence of mouse chromosome 16. Thus, the existence on this mouse chromosome of a newly found locus, designated by us aIr-1, that determines a trans-acting activator function for class II gene expression, is established. Possible implications of this finding are discussed.