Serum cystatin C levels are associated with triglycerides/high-density lipoprotein cholesterol ratio in adolescent girls ages between 16-19 years old
Serum cystatin C levels are associated with triglycerides/high-density lipoprotein cholesterol ratio in adolescent girls ages between 16-19 years old
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DOI：
10.26355/eurrev_202010_23426
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发表时间：
2020-01-01
影响因子：
3.3
通讯作者：
Ninic, A.
中科院分区：
文献类型：
--
作者：
Klisic, A.;Kavaric, N.;Ninic, A.
目的：在年轻人群中，胱抑素C在心脏代谢性疾病中的病理生理学作用尚未完全被研究。另一方面，随着肥胖、血脂异常和胰岛素抵抗(IR)的增加，即使是年轻人也经常被观察到。本研究旨在探讨半胱氨酸氨基转移酶C与甘油三酯/高密度脂蛋白胆固醇比值(TG/HDLc)之间的关系。在16-19岁的青春期女孩队列中，作为血脂异常的指标和IR的替代标记物。提供了人体测量和生化参数。结果：在单因素分析中，血清胱抑素C水平与甘油三酯/高密度脂蛋白胆固醇比值显著相关(OR=1.813；95%CI：1.190~2.757，P=0.005)。此外，多变量分析显示，当体重指数和超敏C反应蛋白(即在Spearman相关分析中与TG/HDLc比率显著相关的标记物)包括在模型中时，Cystatin C是TG/HDLc比率的独立预测因子。调整后的半胱氨酸氨基转移酶C比值比(OR=1.621；95%CI：1.028~2.552，P=0.037)显示，半胱氨酸氨基转移酶C每增加0.1 mg/L，患高甘油三酯/高密度脂蛋白胆固醇组的几率增加1.621倍。还需要进行纵向研究，以确定胱抑素C与甘油三酯/高密度脂蛋白胆固醇比率之间的因果关系，并进一步探讨其在青年人群中诊断和治疗血脂异常和胰岛素抵抗的潜力。
OBJECTIVE: The pathophysiological role of cystatin C in cardiometabolic disorders is not completely explored in young population. On the other hand, together with the increase in obesity, dyslipidemia and insulin resistance (IR) are often observed even in youngsters. The aim of the study was to investigate the relationship between cystatin C and triglycerides-to-high-density lipoprotein cholesterol ratio (TG/HDL-c). as an indicator of dyslipidemia and a surrogate marker of IR in the cohort of adolescent girls ages between 16-19 years.PATIENTS AND METHODS: A total of 99 girls were included in the study. Anthropometric and biochemical parameters were provided. Associations of biochemical markers with TG/HDL-c ratio were tested using univariable and multivariable ordinal regression analysis for TG/HDL-c ratio tertiles as dependent variable.RESULTS: In univariate analysis, cystatin C levels were significantly associated with TG/HDL-c ratio (OR=1.813; 95% Cl: 1.190-2.757, p=0.005). Furthermore, multivariate analysis revealed that cystatin C was an independent predictor of TG/HDL-c ratio when body mass index and high sensitivity C-reactive protein (i.e., markers that were significantly correlated with TG/HDL-c ratio in Spearman's correlation analysis) were included in the Model. Adjusted odds for cystatin C (OR=1.621; 95% CI: 1.028-2.552, p=0.037) demonstrated that rise in cystatin C by 0.1 mg/L increased the probability for higher TG/HDL-c tertile group by 1.621 times.CONCLUSIONS: Serum cystatin C levels are associated with TG/HDL-c ratio in adolescent girls. Longitudinal studies are needed to confirm the causal relationship between cystatin C and TG/HDL-c ratio and to further explore its diagnostic and therapeutic potential in dyslipidemia and insulin resistance in young population.