Psilocybin impairs high-level but not low-level motion perception
Psilocybin impairs high-level but not low-level motion perception
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DOI：
10.1097/00001756-200408260-00023
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发表时间：
2004-08-26
期刊：
影响因子：
1.7
通讯作者：
Vollenweider, FX
中科院分区：
文献类型：
--
作者：
Carter, OL;Pettigrew, JD;Vollenweider, FX
致幻的5-羟色胺(IA&2A)激动剂裸盖菇素以其在静止物体或纹理表面诱导运动错觉的能力而闻名。这项研究调查了裸盖菇素对9名志愿者局部和全局运动处理的影响。使用运动辨别任务的强制选择方向，我们发现裸盖菇素选择性地损害随机点图案的相干敏感性，这可能是由高水平的全局运动检测器介导的，但对漂移光栅的对比度敏感性不是，据信是由低水平的检测器介导的。这些结果与在精神分裂症人群中观察到的结果一致，并针对裸盖菇素可能提供一个模型来研究正常人群中临床精神病和视觉知觉的药理学基础这一命题进行了讨论。
The hallucinogenic serotonin(IA&2A) agonist psilocybin is known for its ability to induce illusions of motion in otherwise stationary objects or textured surfaces. This study investigated the effect of psilocybin on local and global motion processing in nine human volunteers. Using a forced choice direction of motion discrimination task we show that psilocybin selectively impairs coherence sensitivity for random dot patterns, likely mediated by high-level global motion detectors, but not contrast sensitivity for drifting gratings, believed to be mediated by low-level detectors. These results are in line with those observed within schizophrenic populations and are discussed in respect to the proposition that psilocybin may provide a model to investigate clinical psychosis and the pharmacological underpinnings of visual perception in normal populations.