CNS arousal and neurobehavioral performance in a short-term sleep restriction paradigm
CNS arousal and neurobehavioral performance in a short-term sleep restriction paradigm
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DOI：
10.1111/j.1365-2869.2008.00733.x
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发表时间：
2009-09-01
影响因子：
4.4
通讯作者：
Duffus, Shannon E. G.
中科院分区：
文献类型：
--
作者：
Cote, Kimberly A.;Milner, Catherine E.;Duffus, Shannon E. G.
很少有研究调查睡眠限制期间唤醒的清醒电生理测量。这项研究在96小时的实验室方案中检查了脑电图（EEG）活动和表现，其中参与者睡了一个基线夜晚（8小时），被随机分配到3小时，5小时或8小时睡眠组，在接下来的两个晚上进行睡眠限制（SR 1，SR 2），然后睡了一个恢复夜晚（8小时）。在短期的睡眠限制中，情绪、嗜睡和反应时间的测量都出现了剂量依赖性的缺陷。静息时记录的α与θ EEG的比率表明CNS觉醒的剂量依赖性变化。在9：00时，3小时组和5小时组均显示限制期间EEG减慢（嗜睡），3小时组表现出更大的缺陷。在当天晚些时候的13：00，5小时组不再表现出EEG减慢，但3小时组的减慢程度在头皮上更广泛。高频脑电图，一种衡量努力程度的指标，在睡眠限制后的早晨更大。5小时组在限制的两个晚上后中央-顶叶部位的β EEG增加，而3小时组仅在第一个晚上后枕叶区域的β和γ EEG增加。短期睡眠限制会导致表现缺陷以及与睡眠损失的量和持续时间相对应的EEG减慢。高频EEG可能是努力或补偿的标志。
Few studies have investigated waking electrophysiological measures of arousal during sleep restriction. This study examined electroencephalogram (EEG) activity and performance during a 96-hour laboratory protocol where participants slept a baseline night (8 h), were randomly assigned to 3-, 5-, or 8-hour sleep groups for the next two nights sleep restriction (SR1, SR2), and then slept a recovery night (8 h). There were dose-dependent deficits on measures of mood, sleepiness, and reaction time that were apparent during this short-term bout of sleep restriction. The ratio of alpha to theta EEG recorded at rest indicated dose-dependent changes in CNS arousal. At 9:00 hours, both the 3- and 5-hour groups showed EEG slowing (sleepiness) during restriction, with the 3-hour group exhibiting greater deficits. Later in the day at 13:00 hours, the 5-hour group no longer exhibited EEG slowing, but the extent of slowing was more widespread across the scalp for the 3-hour group. High-frequency EEG, a measure of effort, was greater on the mornings following sleep restriction. The 5-hour group had increased beta EEG at central-parietal sites following both nights of restriction, whereas the 3-hour group had increased beta and gamma EEG at occipital regions following the first night only. Short-term sleep restriction leads to deficits in performance as well as EEG slowing that correspond to the amount and duration of sleep loss. High-frequency EEG may be a marker of effort or compensation.