Functional Connectivity Density in Congenitally and Late Blind Subjects
Functional Connectivity Density in Congenitally and Late Blind Subjects
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先天性和晚期失明受试者的功能连接密度
DOI：
10.1093/cercor/bhu051
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发表时间：
2015-09-01
期刊：
影响因子：
3.7
通讯作者：
Yu, Chunshui
中科院分区：
文献类型：
--
作者：
Qin, Wen;Xuan, Yun;Yu, Chunshui
不同发育时期的视觉剥夺导致不同的大脑结构和功能改变；然而，视觉剥夺对大脑自发功能组织的影响在很大程度上仍然未知。在这项研究中，我们使用基于体素的功能连接密度（FCD）分析来研究不同发育时期视觉剥夺对大脑自发功能组织的影响。与正常对照（SC）相比，先天失明（CB）和晚期失明（LB）的初级视觉皮层（V1）的近、远端FCDs均有所下降，初级体感和听觉皮层的远端FCDs均有所下降。虽然大鼠和大鼠在背侧视觉流的近程FCD均有所增加，但与大鼠相比，大鼠在腹侧视觉流和海马复合体的近程和远程FCD均有较大的增加。研究结果表明，发育敏感期前的视觉剥夺比敏感期后的视觉剥夺能诱导更广泛的脑功能重组，这可能是脑后叶处理非视觉信息能力增强的原因。
Visual deprivation during different developmental periods leads to different structural and functional alterations in the brain; however, the effects of visual deprivation on the spontaneous functional organization of the brain remain largely unknown. In this study, we used voxel-based functional connectivity density (FCD) analyses to investigate the effects of visual deprivation during different developmental periods on the spontaneous functional organization of the brain. Compared with the sighted controls (SC), both the congenitally blind (CB) and the late blind (LB) exhibited decreased short-and long-range FCDs in the primary visual cortex (V1) and decreased long-range FCDs in the primary somatosensory and auditory cortices. Although both the CB and LB exhibited increased short-range FCD in the dorsal visual stream, the CB exhibited greater increases in the short-and long-range FCDs in the ventral visual stream and hippocampal complex compared with the LB. Moreover, the short-range FCD of the left V1 exhibited a significant positive correlation with the duration of blindness in the LB. Our findings suggest that visual deprivation before the developmental sensitive period can induce more extensive brain functional reorganization than does visual deprivation after the sensitive period, which may underlie an enhanced capacity for processing nonvisual information in the CB.