Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria
Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria
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DOI：
10.1021/ol050188x
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发表时间：
2005-03-31
期刊：
影响因子：
5.2
通讯作者：
Gerwick, WH
中科院分区：
文献类型：
--
作者：
Andrianasolo, EH;Gross, H;Gerwick, WH
通过对海洋蓝藻的两个野外采集物进行化学研究，发现了两种新的细胞毒性天然产物，即ankaraholide A（2）和B（3），沿着已知化合物swinholide A（1）。由于swinholide型化合物以前定位于海绵的异养细菌，这些发现提出了关于其真正代谢来源的有趣问题。
Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.