Measurement of the Optic Disc Vertical Tilt Angle With Spectral-Domain Optical Coherence Tomography and Influencing Factors
Measurement of the Optic Disc Vertical Tilt Angle With Spectral-Domain Optical Coherence Tomography and Influencing Factors
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DOI：
10.1016/j.ajo.2013.05.036
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发表时间：
2013-10-01
影响因子：
4.2
通讯作者：
Nouri-Mahdavi, Kouros
中科院分区：
文献类型：
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作者：
Hosseini, Hamid;Nassiri, Nariman;Nouri-Mahdavi, Kouros
目的：报道一种测量视神经（ON）头部垂直倾斜角的新方法，并探讨相关因素。设计：横断面诊断研究。方法：112只正常眼、青光眼和疑似青光眼（99例）纳入本研究。受试者接受了全面的眼部检查、生物测定和光谱域光学相干断层扫描（SDOCT）。以Brach膜开口的内缘为参考平面，在通过on头部和中央凹中心的高分辨率横截面SDOCT图像上测量垂直倾斜角。通过单因素和多因素线性回归分析，估计垂直倾斜角度与卵形指数的相关性以及潜在的相关因素。结果：眼轴长度中位数（四分位间距，[IQR]）和视野平均偏差分别为24.5 (23.8-25.3)mm和-0.9 (-2.76 - 0.26)dB。中位（IQR）倾斜角度为3.5（1.2-11.2）度。卵形指数与倾斜角度有中度相关性（Spearman p = 0.351; p < 0.001）。在单变量分析中，轴向长度、球面等效和平均偏差与倾斜角度相关（P = 0.002、P = 0.011和P = 0.013）。在多变量分析中，轴长、平均偏差及其相互作用与倾斜角度的相关性具有统计学意义（轴长P = 0.044，平均偏差P = 0.039，相互作用P = 0.028）。结论：我们描述了一种利用高分辨率SDOCT成像测量ON头垂直倾斜角的新方法。卵形指数显示，只有适度的相关性与倾斜角的测量，因此不是一个很好的代理测量垂直ON头部倾斜角。轴长和视野平均偏差是影响ON头垂直倾斜角度的主要因素。垂直倾斜角度与青光眼严重程度之间关系的基础有待进一步探讨。(C) 2013年Elsevier Inc.版权所有。)
PURPOSE: To report a novel method for measuring the vertical tilt angle of the optic nerve (ON) head and to investigate the associated factors.DESIGN: Cross-sectional diagnostic study.METHODS: One hundred and twelve normal, glaucomatous, and glaucoma suspect eyes (99 patients) were enrolled in this study. Subjects underwent a full eye examination, biometry, and spectral-domain optical coherence tomography (SDOCT). The vertical tilt angle was measured on high-resolution cross-sectional SDOCT images passing through the ON head and foveal centers using the inner edges of the Brach membrane opening as the reference plane. The correlation between the vertical tilt angle with the ovality index and the potential associated factors was estimated with univariate and multivariate linear regression analyses.RESULTS: The median (interquartile range, [IQR]) axial length and visual field mean deviation were 24.5 (23.8-25.3) mm and -0.9 (-2.76 to 0.26) dB. The median (IQR) tilt angle was 3.5 (1.2-11.2) degrees. There was a moderate correlation between the ovality index and tilt angle (Spearman p = 0.351; P < .001). In univariate analyses, axial length, spherical equivalent, and mean deviation were correlated with the tilt angle (P = .002, P = .011, and P = .013, respectively). Axial length, mean deviation, and their interaction showed a statistically significant correlation with the tilt angle in multivariate analyses (P = .044 for axial length, P = .039 for mean deviation, and P = .028 for their interaction).CONCLUSIONS: We describe a new method for measuring the ON head vertical tilt angle with high-resolution SDOCT imaging. The ovality index demonstrated only a moderate correlation with the tilt angle measurements and hence is not a good proxy measure for the vertical ON head tilt angle. Axial length and visual field mean deviation are the main factors associated with the ON head vertical tilt angle. The underlying basis for the relationship of vertical tilt angle and glaucoma severity should be further explored. ((C) 2013 by Elsevier Inc. All rights reserved.)