Neurodegeneration: nicked to death.

Neurodegeneration: nicked to death.
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神经退行性变:被割伤致死。

DOI:
10.1016/j.cub.2006.12.012
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发表时间:
2007
期刊:
Current biology : CB
影响因子:
--
通讯作者:
Mattson,MarkP
Mattson,MarkP
中科院分区:
--
文献类型:
--
作者:
Wilson3rd,DavidM;Mattson,MarkP

文献摘要

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Ataxia oculomotor apraxia-1 is a neurological disorder that arises from mutations in the gene encoding the protein aprataxin. A recent study demonstrates that aprataxin is critical for the processing of obstructive DNA termini, suggesting a broader role for DNA single-strand break repair in neurodegenerative disease.