National Wilms Tumor Study: An update for pathologists
National Wilms Tumor Study: An update for pathologists
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DOI：
10.1007/s100249900010
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发表时间：
1998-01-01
影响因子：
1.9
通讯作者：
Beckwith, JB
中科院分区：
文献类型：
--
作者：
Beckwith, JB
国家肾母细胞瘤研究 (NWTS)-5 于 1995 年 8 月开始，纳入了一些重要的新定义和概念，这些定义和概念对于确定治疗和预后至关重要。 1 期的标准经过改进，以适应 1 期肾母细胞瘤的一个重要子集，这些肿瘤仅通过肾切除术进行治疗，无需使用辅助治疗。肾窦第 1 期和第 2 期之间的区别不再由肺门平面定义，而是由静脉或淋巴管侵犯的存在与否来定义。本文将讨论解释肾窦时遇到的具体问题。局灶性退行性变的地形学定义已被证明具有预后价值，并已纳入 NWTS -5 研究设计中。
The National Wilms Tumor Study (NWTS)-5, begun in August 1995, incorporates some important new definitions and concepts that have critical importance in determining therapy and prognosis. The criteria, for stage 1 were refined to accommodate an important subset of stage 1 Wilms tumors that are being managed by nephrectomy alone, without the use of adjuvant therapy. The distinction between stages 1 and 2 in the renal sinus is no longer defined by the hilar plane but by the presence or absence of venous or lymphatic invasion. Specific problems encountered in the interpretation of the renal sinus are discussed here. The topographical definition of focal anaplasia has proven to be of prognostic value and is incorporated into the NWTS -5 study design.