Distinguishing Molecular Mechanical Action from Photothermal and Photodynamic Behavior.
Distinguishing Molecular Mechanical Action from Photothermal and Photodynamic Behavior.
复制标题
区分分子机械作用与光热和光动力行为。
DOI：
10.1002/adma.202306669
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Beckham JL
中科院分区：
文献类型：
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作者：
Beckham JL
分子马达（MM）是分子机器或纳米机器，其在光刺激下单向旋转并对其环境进行机械功。在过去的几年中，已经表明MM的光机械作用可以用于透化脂质双层，从而杀死癌细胞和病原微生物并控制细胞信号传导。这项工作有助于越来越多地认识到，这些系统的分子驱动特性是有用的，在生物学中的各种应用。然而，分子运动对生物材料的机械效应很难与光动力学和光热作用分开，当用光照射光吸收荧光团时也存在光动力学和光热作用。在这里，概述了各种研究小组用来区分光机械，光动力和光热作用的影响的关键方法。预计这次讨论将有助于社区寻求使用MM开发新的和独特的医疗技术，从生物材料的机械破坏。
Molecular motors (MM) are molecular machines, or nanomachines, that rotate unidirectionally upon photostimulation and perform mechanical work on their environment. In the last several years, it has been shown that the photomechanical action of MM can be used to permeabilize lipid bilayers, thereby killing cancer cells and pathogenic microorganisms and controlling cell signaling. The work contributes to a growing acknowledgement that the molecular actuation characteristic of these systems is useful for various applications in biology. However, the mechanical effects of molecular motion on biological materials are difficult to disentangle from photodynamic and photothermal action, which are also present when a light‐absorbing fluorophore is irradiated with light. Here, an overview of the key methods used by various research groups to distinguish the effects of photomechanical, photodynamic, and photothermal action is provided. It is anticipated that this discussion will be helpful to the community seeking to use MM to develop new and distinctive medical technologies that result from mechanical disruption of biological materials.