In vitro and in vivo performance evaluation of a totally implantable electrohydraulic left ventricular assist system.
In vitro and in vivo performance evaluation of a totally implantable electrohydraulic left ventricular assist system.
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完全植入式电动液压左心室辅助系统的体外和体内性能评估。
DOI：
10.1097/00002480-198907000-00084
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Nosé,Y
中科院分区：
文献类型：
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作者：
Mussivand,T;Fujimoto,L;Butler,K;Rintoul,T;Masterson,K;Navarro,R;Sakakibara,N;Massiello,A;Kiraly,R;Nosé,Y
在14头小牛中测试了生物化电液左心室辅助装置，平均存活时间为162天，在不使用抗凝剂的情况下长达250天。在体外，该系统在4.8 mmHg的低填充压力下泵送4.1 L/min，平均后负荷为100 mmHg，速率为46 bpm。在155 bpm和110 mmHg后负荷下观察到的流速为13.5 L/min。电机频率和电流随着流速的增加而增加（在2.5 L/min时为162 Hz，0.67 amp;在13.5 L/min时为484 Hz，2.43 amp）。流速没有随后负荷压力显著变化。将完整系统植入100 kg小牛体内。在85至167 bpm的心率下证明了血泵与自然心脏的同步。同步流速从6 L/min变化到10.5 L/min，尽管有相当大的心率变化和冲程变化。系统血流动力学性能可接受，符合NIH要求。
The biolized electrohydraulic left ventricle assist devices were tested in 14 calves with an average survival time of 162 days and as long as 250 days without the use of anticoagulants. In vitro, the system pumped 4.1 L/min at a low 4.8 mmHg fill pressure with a mean afterload of 100 mmHg and rate of 46 bpm. A flow rate of 13.5 L/min was observed at 155 bpm and 110 mmHg afterload. Motor frequency and current increased with increasing flow rate (162 Hz, 0.67 amp at 2.5 L/min; 484 Hz, 2.43 amp at 13.5 L/min). Flow rate did not change significantly with afterload pressure. The complete system was implanted in a 100 kg calf. Synchronization of the blood pump with the natural heart was demonstrated at heart rates of 85 to 167 bpm. The synchronized flow rate varied from 6 to 10.5 L/min despite the considerable heart rate changes and stroke variations. The system hemodynamic performances were acceptable and met NIH requirements.