Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats
Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats
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DOI：
10.2337/diabetes.52.3.818
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发表时间：
2003-03-01
期刊：
影响因子：
7.7
通讯作者：
Kowluru, RA
中科院分区：
文献类型：
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作者：
Kowluru, RA
临床和实验研究表明，在血糖控制（PC）不佳的一段时间后，重新建立良好的血糖控制（GC）不会对视网膜病变的进展产生立即的益处，高血糖症足以引发糖尿病视网膜病变的发展。在这项研究中，重建GC对高血糖诱导的增加的氧化应激和硝化应激的影响进行了评估，在大鼠的视网膜保持在PC开始GC之前。在糖尿病大鼠中，PC 2或6个月（GHb >11.0%）后进行GC 7个月（GHb 80%），与正常大鼠或GC期间大鼠相比。这表明视网膜中的氧化和硝化修饰发生在糖尿病视网膜病变发展过程的早期。这些异常不容易通过GC的重新设置而逆转，并且GC开始前PC的持续时间影响逆转的结果。对GC再治疗后视网膜病变对停止的抵抗的异常进行表征将有助于确定未来潜在的抑制糖尿病视网膜病变进展的治疗方法。
Clinical and experimental studies have shown that reinstitution of good glycemic control (GC) after a period of poor glycemic control (PC) does not produce immediate benefits on the progression of retinopathy, and hyperglycemia is sufficient to initiate the development of diabetic retinopathy. In this study, the effect of reinstitution of GC on hyperglycemia-induced increased oxidative stress and nitrative stress was evaluated in the retina of rats maintained in PC before initiation of GC. In diabetic rats, 2 or 6 months of PC (GHb >11.0%) was followed by 7 months of GC (GHb 80% compared with normal rats or rats kept in GC for the duration. This suggests that oxidative and nitrative modifications in retina occur early in the course of development of retinopathy in diabetes. These abnormalities are not easily reversed by reinstitution of GC, and the duration of PC before initiation of GC influences the outcome of the reversal. Characterization of the abnormalities responsible for the resistance of retinopathy to arrest after reinstitution of GC will help identify potential future therapies to inhibit progression of diabetic retinopathy.