Development of an aerosol dispersion test to detect early changes in lung function.
Development of an aerosol dispersion test to detect early changes in lung function.
复制标题
开发气溶胶分散测试以检测肺功能的早期变化。
DOI：
10.1080/15298668891379891
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Lippmann,M
中科院分区：
文献类型：
--
作者：
McCawley,M;Lippmann,M
The dispersion of a 0.5 µm aerosol bolus during tidal breathing differs significantly (p<0.0001) between a group of smokers (with ∼20 pack-years average exposure) and a comparable group of nonsmokers. Their mean differences in standard respiratory function indexes from spirometry [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), mean forced expiratory flow during the middle half of the FVC (FEF25–75)] were smaller and not statistically significant. The test is simple to perform and may be done as quickly as spirometry but without using a forced exhalation. Comparison of the coefficients of variation for the dispersion test and FEV1indicate that the aerosol dispersion test may be useful in epidemiologic investigations either by reducing the required population size or increasing the level of confidence.
